The efficacy of ferrous bisglycinate and electrolytic iron as fortificants in bread in iron-deficient school children

The British Journal of Nutrition
Martha E van StuijvenbergMuhammad A Dhansay

Abstract

Food fortification is an important long-term strategy for addressing micronutrient deficiencies. Finding the ideal Fe fortification compound, however, remains a challenge. In the present study the effect of ferrous bisglycinate as fortificant in brown bread was compared with that of electrolytic Fe among Fe-deficient school children in a randomised controlled trial. Children (n 160), aged 6-11 years, with serum ferritin <20 microg/l, were randomly assigned to one of three treatment categories: (i) standard unfortified bread; (ii) bread with electrolytic Fe as fortificant; and (iii) bread with ferrous bisglycinate as fortificant. Each child received four slices of bread (120 g) on school days, which supplied an average of 3.66 mg elemental Fe per intervention day for 137 d (2.52 mg/d for 75 d and 5.04 mg/d for 62 d) over a period of 7.5 months. Hb, serum ferritin, serum Fe and transferrin saturation were measured at baseline and at the end of the intervention. Significant treatment effects were observed for Hb (P = 0.013), serum Fe (P = 0.041) and transferrin saturation (P = 0.042) in the ferrous bisglycinate group, but not in the electrolytic Fe group. There were no significant intervention effects for serum ferritin in either ...Continue Reading

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Citations

Apr 8, 2010·Critical Reviews in Food Science and Nutrition· Salim-Ur-RehmanWazir Hussain Shah
Aug 19, 2007·Lancet·Michael B Zimmermann, Richard F Hurrell
Jan 22, 2008·Lancet·Zulfiqar A BhuttaUNKNOWN Maternal and Child Undernutrition Study Group
Apr 29, 2009·International Journal of Food Sciences and Nutrition·Bruno T SoeiroJuliana A Lima-Pallone
Oct 22, 2010·The American Journal of Clinical Nutrition·Michael B ZimmermannRichard F Hurrell
Jan 16, 2007·Cadernos de saúde pública·Maria Cecília F Assunção, Iná S Santos
Mar 29, 2020·International Journal of Sport Nutrition and Exercise Metabolism·Rachel McCormickPeter Peeling
Jan 19, 2021·The Cochrane Database of Systematic Reviews·Martha S FieldJuan Pablo Peña-Rosas

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