The Efficacy of Fibrin Sealant Patches in Reducing the Incidence of Lymphatic Morbidity After Radical Lymphadenectomy: A Meta-Analysis

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Maria Luisa GasparriAndrea Papadia

Abstract

Although pivotal in the oncological management of most tumors, radical lymphadenectomy is associated with a significant number of lymphatic complications. The aim of this meta-analysis is to evaluate the efficacy of fibrinogen sealant patches in reducing lymphadenectomy-related postoperative complications. The electronic databases PubMed, Medline, and Scopus were searched using the terms "lymphadenectomy" or "lymph node dissection" and "TachoSil," "TachoComb," or "fibrin sealant patch." Series evaluating the efficacy of fibrin-thrombin collagen sealant patches were included in the meta-analysis. Overall, 26 studies were retrieved through the literature search. Ten studies including 720 patients met selection criteria. The use of fibrin-thrombin sealant patches to the sole scope of reducing lymphadenectomy-related complications significantly reduced the incidence of lymphocele, symptomatic lymphocele, the need of percutaneous drainage procedures, the volume of lymph drained, and the duration of the drainage. No effect on wound and/or lymphocele infection was noted. This meta-analysis demonstrates that the use of fibrin-thrombin sealant patches significantly reduces the total volume of lymph drained, the duration of the drainage,...Continue Reading

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Citations

Nov 21, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Şener Gezerİzzet Yücesoy
Oct 16, 2018·Minerva ginecologica·Andrea PapadiaMichael D Mueller
Jun 28, 2018·Annals of Surgical Oncology·Walter Paul WeberUNKNOWN Swiss Group for Clinical Cancer Research (SAKK)
Nov 22, 2018·Journal of Cancer Research and Clinical Oncology·Maria Luisa GasparriMichael D Mueller
Apr 18, 2018·The British Journal of Surgery·M SchindlUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Apr 18, 2019·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·R N KomarovD B Andreev
Aug 14, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Anastasios TranoulisStephen Attard Montalto

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