The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: A meta-analysis

Medicine
Yun-Feng JiangJun Xiong

Abstract

The purpose of this meta-analysis from randomized controlled trials (RCTs) was to determine the efficacy and safety of the preoperative use of gabapentin for the treatment of acute and chronic postoperative pain following breast cancer surgery. In November 2017, a systematic computer-based search was conducted in PubMed, Embase, Web of Science, Cochrane Library, and Google databases. RCTs comparing gabapentin with placebo in patients undergoing breast cancer surgery were retrieved. The primary endpoint was the visual analog scale (VAS) after surgery and 24 hours after surgery and total morphine consumption. The secondary outcomes were incidence of chronic pain and complications (the incidence of nausea). Software Stata 12.0 was used for meta-analysis. Finally, 9 RCTs were included in the meta-analysis. Results indicated that gabapentin was associated with reduced pain scores after surgery and 24 hours after surgery. Meanwhile, oral gabapentin was associated with a reduction of the total morphine consumption after breast cancer surgery. Similarly, gabapentin was associated with a reduction in the incidence of chronic pain and the incidence of nausea. Preoperative use of gabapentin was able to reduce acute and chronic postoperati...Continue Reading

References

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Citations

Jul 25, 2019·Current Opinion in Anaesthesiology·Amanda H Kumar, Ashraf S Habib
Jun 13, 2020·Journal of Plastic Surgery and Hand Surgery·Limin CaiDunwei Wang
Mar 10, 2020·World Journal of Clinical Cases·Ying-Jie HaoYing-Li Li
Dec 19, 2020·The Journal of International Medical Research·Jie NiRui-Fang Sun
Jun 1, 2020·The Journal of Surgical Research·Victoria HuynhSarah Tevis
Dec 8, 2020·Current Anesthesiology Reports·Maria F RamirezJuan P Cata
Aug 30, 2019·Life Sciences·Heba M FahmyWael M Elshemey
Jun 17, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lei TengHuichao Zou

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Methods Mentioned

BETA
dissection
hip arthroplasty

Software Mentioned

Endnote
Stata
GetData Graph Digitizer
Review Manager
GRADE Pro

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