The efficacy of gastrectomy for large gastric cancer

International Journal of Clinical Oncology
Osamu KobayashiMotonori Sairenji

Abstract

Large gastric cancer (LGC) is frequently associated with extended disease, and the role of surgical resection has been debated. We investigated the efficacy of surgical treatment for LGC. The size of LGC was defined as 8 cm or greater. Four hundred and fifteen patients with LGC who underwent gastrectomy were included. The clinicopathological features, the status of the residual tumor, the incidence and patterns of relapse, and the survival were analyzed. Macroscopically, diffuse-type tumors were dominant (60%). The numbers of patients with tumors of T3 or greater, lymph node involvement, and peritoneal metastases were 356 (86%), 359 (87%), and 126 (30%), respectively. One hundred and eighty-eight patients (45%) underwent incomplete tumor resection (R2). The R2/R0 (no residual tumor) ratio was greater than 1 in patients with type 4 tumors and N1 or greater metastasis and in those with type 3 tumors and N2 or greater metastasis. In contrast, T2, type 2, and type 5 tumors were more likely to be completely resected. The 5-year survival for all 415 patients was 26%. The survival rates were inversely related to the tumor type, size, and lymph node metastasis. In the 216 patients with R0, the 5-year survivals of those with pN (Interna...Continue Reading

References

Oct 1, 1992·Journal of Surgical Oncology·H BabaK Sugimachi
Sep 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H WilkeH Knipp
Aug 1, 1987·World Journal of Surgery·K MaruyamaT Kinoshita
Nov 17, 1993·Journal of the National Cancer Institute·J A AjaniD A Vena
Mar 1, 1997·Annals of Surgical Oncology·Y AdachiK Sugimachi
Nov 5, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M MoriartyR E Ferrell
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y SakataT Taguchi
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I SongunC J van de Velde
Jun 20, 2001·The British Journal of Surgery·K YasudaS Kitano
Apr 17, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Atsushi NashimotoNobuhiro Akiyama
Dec 20, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshitaka YamamuraMasashi Goto
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuUNKNOWN Japan Clinical Oncology Group Study (JCOG9205)
May 31, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Haruhiko ChoToshio Imada
May 31, 2003·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Taira KinoshitaShigeaki Yoshida
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi NashimotoUNKNOWN Gastric Cancer Surgical Study Group, Japan Clinical Oncology Group
Aug 29, 2003·The British Journal of Surgery·F RovielloUNKNOWN Italian Research Group for Gastric Cancer

❮ Previous
Next ❯

Citations

Sep 16, 2008·Langenbeck's Archives of Surgery·Kyong Hwa JunWoo Bae Park
Mar 31, 2011·World Journal of Gastroenterology : WJG·Naoto FukudaJoji Wada
Nov 7, 2009·Asian Journal of Surgery·Jong-Han KimChong-Suk Kim
Oct 11, 2008·Journal of Cancer Research and Clinical Oncology·Lin Sheng-ZhangZhang Wei
Jul 2, 2019·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Luyang ZhangWei-Guo Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Taira KinoshitaShigeaki Yoshida
The British Journal of Surgery
H H HartgrinkDutch Gastric Cancer Group
Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
David M Roder
Surgical Oncology Clinics of North America
Y YonemuraT Sasaki
Journal of Surgical Oncology
Norio ShiraishiSeigo Kitano
© 2021 Meta ULC. All rights reserved