Abstract
In a two-week double-blind trial l-methadone and racemic methadone were compared for efficacy in substitution treatment for opiate addicts. Before the trial the twenty-six participants had been on stable doses of l-methadone. Patients with evidence of current serious psychological problems were excluded. Patients were evaluated twice a week using a modified FSUCL, physician's withdrawal checklist, self-rating withdrawal scale, and the Beschwerden-Liste (complaint list) according to von Zerssen. Between addicts continuing on l-methadone (n = 13) and those now receiving racemic methadone (n = 13) there were no statistically significant differences. In particular, patients receiving racemic methadone did not complain more frequently of withdrawal symptoms. In a follow-up period of nine weeks after replacement of l-methadone with racemic methadone, there was also no significant increase in complaints about withdrawal symptoms, although six patients needed an elevation of their daily dosage by at least 20 mg racemic methadone.
Citations
May 27, 2005·Drug and Alcohol Dependence·Uwe VertheinChristian Haasen
Nov 9, 2000·British Journal of Clinical Pharmacology·D J FosterF Bochner
Jun 16, 2006·Der Anaesthesist·J Jage, F Heid
Mar 4, 2014·Substance Abuse Treatment, Prevention, and Policy·Jens ReimerStephan Walcher
May 27, 2005·Journal of Psychoactive Drugs·Grace A Rowan-SzalD Dwayne Simpson
Jan 6, 2006·Substance Use & Misuse·S GiacomuzziY Riemer
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Afarin Rahimi-MovagharReza Yousefi-Nooraie
Sep 29, 2005·British Journal of Clinical Pharmacology·Julia HannaFelix Bochner
Oct 31, 2002·Clinical Pharmacokinetics·Chin B EapPierre Baumann
Jul 25, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael Soyka, Christina Zingg
Dec 18, 2012·European Journal of Anaesthesiology·Waltraud StromerAndreas Sandner-Kiesling
May 20, 2003·Addiction·S M GiacomuzziM Kurz
Jun 26, 1999·British Journal of Clinical Pharmacology·A Rostami-HodjeganG T Tucker
Apr 14, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael SoykaUNKNOWN WFSBP Task Force on Treatment, Guidelines for Substance Use Disorders
Nov 26, 2004·British Journal of Clinical Pharmacology·Timothy B MitchellJason M White