Jun 2, 2020

The Efficacy of Lidocaine in Disrupting Cocaine Cue-Induced Memory Reconsolidation

Drug and Alcohol Dependence
Josh E BeckerBryon Adinoff

Abstract

Cue-induced craving memories, linked to drug-seeking behaviors, require key molecular processes for memory reconsolidation. Lidocaine, a sodium channel blocker, inhibits NMDA receptor activation and suppresses nitric oxide and ERK production. These processes are required for memory re-consolidation; inhibiting them may reduce cue-related craving memories in cocaine dependent subjects. To assess the efficacy of lidocaine in decreasing cue-induced cocaine craving and cocaine use. Treatment-seeking cocaine-dependent participants (n = 33, 25 men) were recruited. Personalized craving and relaxation scripts were developed. Participants were then randomly assigned in a double-blind design to either receive intravenous lidocaine immediately following a cocaine craving script (lidocaine/craving), saline following a craving script (saline/craving), or lidocaine following a relaxation script (lidocaine/relax). One week following the infusion, cue-induced craving was assessed in the same paradigm without an infusion. Cocaine use and craving were assessed for 4 weeks following infusion. The administration of lidocaine during craving induction (lidocaine/craving) did not decrease cue-induced craving during craving reactivation one week later...Continue Reading

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Mentioned in this Paper

Script
Administration Procedure
Nitric Oxide
Lidocaine
Craves for Drugs
Mitogen-Activated Protein Kinases
Memory
Follow-up
Infusion Procedures
IV Lidocaine

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