PMID: 2511299Jan 1, 1989Paper

The efficacy of low-dose lithium: clinical, psychological and biological correlates

Journal of Psychiatric Research
M T Abou-Saleh, A Coppen

Abstract

The relationships between lithium dosage, affective morbidity, side-effects, thyroid and renal function and biological markers for depression were examined in the context of a prospective double-blind lithium reduction study in patients receiving prophylactic lithium. Unipolar and bipolar patients on such treatment were randomly allocated to two groups over a period of one year, either continuing with their usual dosage of lithium or reducing their lithium dosage by up to 50%. Biological markers investigated included dexamethasone suppression test (DST) and 5-hydroxytryptamine (5-HT) transport into platelets (Vmax). Results showed no association between affective morbidity and lithium dosage/level. There was, however, an association between lower dosage/level of lithium and lower side-effects, including tremor and weight gain, lower TSH levels and lower 24 h urinary volume in these patients. Elderly patients, however, experienced significantly greater morbidity upon reduction of their lithium dosage. There was an association between increased Vmax of 5-HT transport and a reduction in morbidity. DST non-suppression was associated with lower mean weight for the whole year of the study.

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Citations

Nov 14, 1992·Lancet·T S BrughaS Checkley
Dec 1, 1992·Journal of Clinical Pharmacy and Therapeutics·J Krska, D A Corner
Dec 11, 2008·Psychiatry and Clinical Neurosciences·Beatriz ArbaizarJavier Llorca
Nov 8, 2014·Harvard Review of Psychiatry·Rajnish MagoRajeev Mahajan
Jul 12, 2002·International Journal of Geriatric Psychiatry·David WilkinsonJanine North
Aug 24, 2013·The Australian and New Zealand Journal of Psychiatry·Ji Hyun BaekAndrew A Nierenberg
Jan 23, 1993·BMJ : British Medical Journal·R F Kehoe
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Nov 19, 2015·Frontiers in Neuroscience·Carol A Lazzara, Yong-Hwan Kim
Jan 23, 1993·BMJ : British Medical Journal·D J DoneT J Crow
Dec 3, 2016·International Journal of Bipolar Disorders·Michael Gitlin
Jan 1, 1992·Journal of Psychopharmacology·M T Abou-Saleh
May 1, 2021·Biomedicines·Alexandre ValléeYves Lecarpentier

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