The efficacy of low dose metoprolol CR/ZOK in mild hypertension and in elderly patients with mild to moderate hypertension

Journal of Clinical Pharmacology
A JäätteläG Westergren

Abstract

In two separate but similarly designed placebo-controlled studies, the efficacy of metoprolol CR/ZOK 50 mg once daily was evaluated in 64 patients (mean age 53 years) with mild hypertension (Study I) and in 34 elderly patients (mean age 68 years) with mild to moderate hypertension (Study II). Both studies were of randomized, double-blind, parallel-group design, the entry criteria for diastolic blood pressure being greater than or equal to 90 less than 105 mm Hg in Study I and greater than or equal to 95 less than 110 mm Hg in Study II. Study I: The impact of metoprolol CR/ZOK 50 mg once daily for 4 weeks compared with placebo 24 hours post dosing was to produce a significant reduction in supine (P = .0001), and standing (P less than .0001) systolic blood pressures and the standing diastolic pressure (P = .035). The supine diastolic pressure was lower after metoprolol CR/ZOK but not significantly so. Study II: Metoprolol CR/ZOK 50 mg daily given to elderly hypertensives when compared with placebo 24 hours post dosing produced a significant fall in supine (P = .022) and standing (P = .022) diastolic pressure. Systolic pressure and heart rate were not significantly reduced. One patient in Study II had a nonfatal myocardial infarct...Continue Reading

References

Jan 1, 1990·European Journal of Clinical Pharmacology·E S DimenäsP W Lücker
Dec 1, 1988·British Journal of Clinical Pharmacology·D J SumnerH L Elliott
Jun 26, 1986·The New England Journal of Medicine·S H CroogG H Williams
Jan 1, 1974·Stroke; a Journal of Cerebral Circulation·R B ShekelleH L Klawans
Jun 19, 1980·The New England Journal of Medicine·J Koch-WeserE O'Brien
Nov 10, 1983·The American Journal of Cardiology·A V Chobanian
Nov 1, 1980·The American Journal of Medicine·A Helgeland
Dec 1, 1981·Southern Medical Journal·A J Wood, J Feely
Nov 20, 1980·The New England Journal of Medicine

❮ Previous
Next ❯

Citations

Aug 14, 2002·Journal of Clinical Pharmacy and Therapeutics·M J LandrayM J Kendall
Mar 11, 2016·The Cochrane Database of Systematic Reviews·Gavin W K WongJames M Wright

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.