The efficacy of mesenchymal stromal cell-derived therapies for acute respiratory distress syndrome-a meta-analysis of preclinical trials.

Respiratory Research
Wang FengyunLixin Zhou

Abstract

The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to investigate the efficacy of MSC-derived therapies (MDTs) for ALI/ARDS in animal models. A meta-analysis of MDTs for ALI/ARDS in animal trials was performed. PubMed and EMBASE were searched to screen relevant preclinical trials with a predetermined search strategy. A total of 17 studies that compared MDT with the ALI control group were included in our study. The pooled result derived from the comparison of the two groups suggested that MDT could significantly reduce the lung injury score (standardized mean difference (SMD) = - 4.02, 95% CI [- 5.28, - 2.23], P < 0.0001) and improve animal survival (OR = - 6.45, 95% CI [2.78, 14.97], P < 0.0001). MDT mitigated the infiltration of neutrophils in alveoli (SMD = - 3.38, 95% CI [- 4.58, - 2.18], P < 0.00001). MDT also reduced the wet-dry weight ratio of the lung (SMD = - 2.34, 95% CI [- 3.42, - 1.26], P < 0.0001) and the total protein in BALF (SMD = - 2.23, 95% CI [- 3.07, - 1.40], P ...Continue Reading

References

Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jul 23, 2004·The New England Journal of Medicine·Roy G BrowerUNKNOWN National Heart, Lung, and Blood Institute ARDS Clinical Trials Network
Feb 17, 2005·American Journal of Physiology. Renal Physiology·Florian TögelChristof Westenfelder
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveen GuptaMichael A Matthay
Sep 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jae W LeeMichael A Matthay
Oct 2, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lavinia IonescuBernard Thébaud
May 22, 2013·The New England Journal of Medicine·Claude GuérinUNKNOWN PROSEVA Study Group
Dec 23, 2014·The Lancet. Respiratory Medicine·Jennifer G WilsonMichael A Matthay
Feb 19, 2015·The New England Journal of Medicine·Marcelo B P AmatoRoy G Brower
Apr 15, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sweta RaniThomas Ritter
Jun 13, 2015·American Journal of Respiratory and Critical Care Medicine·Antoine MonselJae W Lee
Oct 8, 2015·Nature Communications·Donald G PhinneyLuis A Ortiz
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Giacomo BellaniUNKNOWN ESICM Trials Group
Aug 2, 2016·Chest·Gerard F CurleyArthur S Slutsky
Aug 12, 2016·American Journal of Respiratory and Critical Care Medicine·Katie R FamousUNKNOWN ARDS Network
May 2, 2017·American Journal of Respiratory and Critical Care Medicine·Eddy FanUNKNOWN American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine
Oct 4, 2017·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) InvestigatorsCarlos Roberto Ribeiro de Carvalho
Feb 22, 2018·JAMA : the Journal of the American Medical Association·Eddy FanArthur S Slutsky
Nov 2, 2018·Transfusion·Laura A HuppertMichael A Matthay
Nov 11, 2018·Respiratory Research·Arezoo MohammadipoorLeopoldo C Cancio
Nov 24, 2018·Proteomics·Bas W M van BalkomSai Kiang Lim
Jan 16, 2019·Journal of Tissue Engineering and Regenerative Medicine·Tarini Nawamalie Abeysinghe GunawardenaNoor Hayaty Abu Kasim
Mar 16, 2019·Nature Reviews. Disease Primers·Michael A MatthayCarolyn S Calfee
Mar 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qing-Chun LiZhen-Bo Su
May 7, 2019·Seminars in Respiratory and Critical Care Medicine·Laura A HuppertLorraine B Ware

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