The efficacy of pain control following nonsurgical root canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo-controlled study

International Endodontic Journal
K A MenhinickP H Buschang

Abstract

To compare ibuprofen, to an ibuprofen/acetaminophen combination in managing postoperative pain following root canal treatment. It is hypothesized that the drug combination will provide more postoperative pain relief than the placebo or ibuprofen alone. Patients presenting at the Texas A&M Baylor College of Dentistry's graduate endodontic clinic, experiencing moderate to severe pain, were considered potential candidates. Fifty-seven patients were included based on established criteria. Following administration of local anaesthesia, a pulpectomy was performed. The patients were administered a single dose of either: (i) placebo; (ii) 600 mg ibuprofen; or (iii) 600 mg ibuprofen and 1000 mg of acetaminophen. Patients recorded pain intensity following treatment on a visual analogue scale and a baseline four-point category pain scale as well as pain relief every hour for the first 4 h then every 2 h thereafter for a total of 8 h. A general linear model (GLM) analysis was used to analyse the outcome. Based upon the GLM analysis, there was a significant difference between the ibuprofen and the combination drug group, and between placebo and combination drug groups. There was no significant difference between the placebo and the ibuprofe...Continue Reading

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Citations

Mar 10, 2016·Journal of Conservative Dentistry : JCD·Malasiddappa MetriShilpa Bhandi
Feb 24, 2006·European Journal of Pain : EJP·Luis RomundstadHarald Breivik
Jan 19, 2006·Australian Dental Journal·K Hargreaves, P V Abbott
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Mar 4, 2015·Journal of Endodontics·Anita Aminoshariae, Asma Khan
Mar 23, 2011·Journal of Endodontics·Jaclyn G Pak, Shane N White
Nov 23, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Bun San Chong, Thomas R Pitt Ford
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Jul 5, 2018·Brazilian Dental Journal·Adrian Camargo Amaral Jorge-AraújoMárcia Thaís Pochapski
Oct 17, 2017·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Wail M ElzakiYahia E Ibrahim
Jul 5, 2019·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·J EvangelinVijay Velu
Jul 12, 2020·Clinical Oral Investigations·Paula Barcellos da SilvaMarcus Vinícius Reis Só
Jan 1, 2015·The Journal of Contemporary Dental Practice·Leena Alsomadi, Riyad Al Habahbeh
Oct 8, 2021·Drugs·Asma A Khan, Anibal Diogenes

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