The efficacy of probiotics in prevention of urinary tract infection in children: A systematic review and meta-analysis

Journal of Pediatric Urology
Mostafa HosseiniAnahita Izadi

Abstract

A consensus has not been reached yet about the efficacy of probiotics in reducing the incidence of urinary tract infections (UTIs) in children. This systematic review and meta-analysis was designed to assess the efficacy of probiotics in prevention UTI in children. The present study was designed based on guidelines for systematic reviews of clinical trials. Two independent reviewers performed an extensive search in the Medline, Embase, Web of Science and Scopus electronic databases up to the end of 2016. The summery of eligible studies was assessed independently by two reviewers and recorded in the data extraction form. Finally, a pooled relative risk (RR) was reported with a 95% confidence interval (95% CI). Data from 10 studies were entered in the present meta-analysis. Probiotic therapy did not have any beneficial effect on the incidence of UTI (RR = 0.94; 95% CI 0.85-1.03; p = 0.19) and its recurrence (RR = 0.93; 95% CI 0.85-1.02; p = 0.14). Subgroup analyses showed that probiotics as monotherapy do not have any beneficial effects on prevention of UTI (RR = 0.96; 95% CI 0.89-1.04; p = 0.31). However, the incidence of UTI is reduced if probiotics are used as adjuvant therapy to antibiotics (RR = 0.92; 95% CI 0.85-0.99; p = 0...Continue Reading

Citations

Jan 15, 2019·Beneficial Microbes·S S KaraI Erten
May 18, 2019·Journal of the Pediatric Infectious Diseases Society·S Sadeghi-BojdF Assadi
Feb 17, 2021·Journal of Pediatric Urology·Lisette A 't HoenRaimund Stein
May 25, 2021·Clinical Nutrition ESPEN·Iva HojsakKoen Joosten

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