The efficacy of single-high dose inhaled corticosteroid versus oral prednisone treatment on exhaled leukotriene and 8-isoprostane levels in mild to moderate asthmatic children with asthma exacerbation

Allergologia et immunopathologia
O KeskinY Coskun

Abstract

The anti-inflammatory effect of high-dose inhaled corticosteroids (ICS) in children with asthma exacerbation is unknown. We aimed to investigate the efficacy of single-high dose ICS versus oral prednisone treatment followed by a course of six day high-dose ICS or oral prednisone (P) treatment on the concentrations of Cys-LTs and 8-isoprostane levels in the exhaled breath condensate (EBC) of children with asthma exacerbation. Ninety-four children with moderate-severe asthma exacerbation were evaluated with asthma scores, peak expiratory flow rate (PEF), forced expiratory volume in first second (FEV1) and exhaled Cys-LT and 8-isoprostane levels before and after treatment. EBC was collected from 52 patients before and four hours after treatment with inhaled fluticasone propionate (FP) (4000μg) or P and after six days of treatment with FP-1000μg/day or P. Cys-LTs and 8-isoprostane concentrations were determined using a specific immunoassay kit. Both single high-dose FP (n=59) and p (n=35) treatment resulted in a significant improvement in asthma score (p<0.0001), PEF (p<0.0001), and FEV1 (p<0.0001). Cys-LT concentration in the EBC decreased significantly both after the initial treatment (p=0.001), and at the end of the six-day peri...Continue Reading

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Citations

Jul 4, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yi XiaoMaurice R O'Gorman
Mar 12, 2019·The Journal of Clinical Investigation·Ioana Agache, Cezmi A Akdis
May 21, 2019·Frontiers in Pediatrics·Michiel A G E BannierEdward Dompeling
Jul 28, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Carlos Ochoa SangradorMaría Victoria Martínez Rubio
Jul 3, 2021·Journal of Clinical Medicine·Joanna PołomskaBarbara Sozańska

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