The efficacy of sulfadoxine-pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesis

Tropical Medicine & International Health : TM & IH
Ishraga E A-ElbasitHayder A Giha

Abstract

To compare the efficacy of sulfadoxine-pyremethamine (SP)+chloroquine (CQ) combination treatment against falciparum malaria with SP treatment alone. In-vivo study of 254 patients with uncomplicated Plasmodium falciparum malaria in rural eastern Sudan, where the population is semi-immune. Sulfadoxine-pyremethamine treatment alone cured 68.3% (41/60) and SP+CQ cured 63.4% (123/194). Early and late treatment failures occurred in both treatment groups. Host age (as a marker for immunity) and parasite gametocytogenesis (as a marker for transmissibility) were significantly associated with SP resistance. Patients who were cured were significantly older (median age 21 years) than patients whose treatment failed (median age 12 years). Gametocyte production was significantly higher in patients with treatment failure (0.72 vs 0.45) and associated with younger age. Gametocyte counts were comparable between both groups until day 7 of follow up; thereafter, they were significantly higher in patients with treatment failure. However, the longevity of gametocytes was comparable in both treatment groups. Chloroquine did not improve the parasite response to SP. Age was strongly associated with clearance of SP-resistant parasites. The fast rise of...Continue Reading

References

Jul 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·M E IbrahimE R el Mubarak
May 9, 1998·The American Journal of Tropical Medicine and Hygiene·H A GihaL Hviid
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·K A BojangB M Greenwood
Sep 30, 1998·Lancet·K Marsh
May 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T G Theander
Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N White
Apr 5, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·B R OgutuG D Shanks
Feb 24, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·H A GihaT G Theander
Sep 15, 2001·Antimicrobial Agents and Chemotherapy·P CravoM J Mackinnon
Jan 5, 2002·Trends in Parasitology·C H SibleyA M Nzila
Jun 10, 2003·Parasitology·A A Abdel-MuhsinH A Babiker
Apr 23, 2005·Acta Tropica·David WallikerHamza Babiker
Apr 29, 2005·Acta Tropica·Hamza A BabikerDavid Walliker

❮ Previous
Next ❯

Citations

Apr 1, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I E A-ElbasitH A Giha
May 28, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sekineh PirahmadiSedigheh Zakeri
Jul 7, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hayder A GihaGehad Elghazali
Apr 22, 2016·Malaria Journal·Susana CampinoTaane G Clark
Mar 11, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hayder A GihaDavid Arnot
Oct 19, 2012·Journal of Medicinal Chemistry·Odile Dechy-Cabaret, Françoise Benoit-Vical
Apr 30, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Muzamil M Abdel HamidAbdelrahim O Mohamed
Feb 20, 2020·Malaria Journal·Abdelrahim O MohamedMuzamil Mahdi Abdel Hamid
Apr 30, 2021·Frontiers in Cellular and Infection Microbiology·Ashleigh RoberdsV Ann Stewart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.