PMID: 8951803Nov 1, 1996Paper

The efficacy of surgical treatment of breast cancer

Medical Hypotheses
D J Benjamin

Abstract

The purpose of the analysis was to resolve the two opposing claims regarding the efficacy of surgical treatment of breast cancer, namely the course of the disease is not affected by surgery because breast cancer is an incurable systemic disease, as shown by a previous analysis, results of randomized breast cancer treatment trials and long-term follow-up of breast cancer patients; and breast cancer can be cured if detected early, as shown by reduced breast cancer mortality observed in results from randomized breast cancer-screening trials using mammograms. Seven randomized breast cancer-screening trials commonly cited as having produced evidence for reduced breast cancer mortality were analysed to identify any flaws in the trial design that would lead to confounding factors that could have affected the results. Flaws were identified in all trials in that the treatment protocols, by requiring that the type and degree of treatment depended on the stage of the tumour at diagnosis, required that up five factors were varied in each trial, confounding the results. Correlations were sought between some of these factors and the breast cancer mortality reduction observed in some screened groups to determine which factors had the main inf...Continue Reading

References

Jan 1, 1992·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·U Abel
Oct 29, 1992·The New England Journal of Medicine·M J McKay, A O Langlands
Mar 1, 1991·Breast Cancer Research and Treatment·J FrisellA Somell
Jan 1, 1990·Journal of Clinical Epidemiology·J G Schmidt
Mar 1, 1989·Journal of Epidemiology and Community Health·F AlexanderW Hepburn

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Citations

Feb 1, 2014·Medical Hypotheses·Donald J Benjamin
Jun 1, 1997·Journal of Women's Health
Jun 6, 2013·The Cochrane Database of Systematic Reviews·Peter C Gøtzsche, Karsten Juhl Jørgensen

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