The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice.

Neurotoxicology
Isaac DengLarisa Bobrovskaya

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease, characterised by the loss of dopaminergic neurons in the substantia nigra. Mounting evidence indicates a crucial role of inflammation and concomitant oxidative stress in the disease progression. Therefore, the aim of this study was to investigate the ability of systemically administered lipopolysaccharide (LPS) to induce motor and non-motor symptoms of PD, inflammation, oxidative stress and major neuropathological hallmarks of the disease in regions postulated to be affected, including the olfactory bulb, hippocampus, midbrain and cerebellum. Twenty-one male C57BL/6 mice, approximately 20 weeks old, received a dose of 0.3 mg/kg/day of LPS systemically on 4 consecutive days and behavioural testing was conducted on days 14-18 post-treatment, followed by tissue collection. Systemically administered LPS increased latency time in the buried food seeking test (indicative of olfactory impairment), and decreased time spent in central zone of the open field (anxiety-like behaviour). However, there was no change in latency time in the rotarod test or the expression of tyrosine hydroxylase (TH) in the midbrain. Systemically administered LPS induced increased gli...Continue Reading

References

Jan 1, 1993·Neuroscience·P DamierF Javoy-Agid
Jan 23, 1998·Brain Research. Brain Research Protocols·G RozasJ L Labandeira-García
Apr 24, 2003·Occupational and Environmental Medicine·I Niehaus, J H Lange
Jun 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Evelien HuismanPiet V Hoogland
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
Mar 20, 2009·Lancet Neurology·Etienne C Hirsch, Stéphane Hunot
Oct 23, 2009·Journal of Neurology·Paula ScalzoAntônio Lúcio Teixeira
Feb 12, 2010·Annals of the New York Academy of Sciences·Glenda Margaret Halliday, Heather McCann
Mar 10, 2010·Behavioural Brain Research·Tonya N TaylorGary W Miller
May 25, 2010·Nature Medicine·Jose A ObesoGlenda Halliday
May 10, 2011·Acta Neuropathologica·Iñaki-Carril MundiñanoMaria-Rosario Luquin
May 16, 2012·Nature Reviews. Neurology·Richard L Doty
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mechelle M LewisMartin J McKeown
Feb 11, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lucian Hritcu, Lucian Dragos Gorgan
Jun 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Leo P KellyJeffrey H Kordower
Jun 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liviu-Gabriel BodeaHarald Neumann
Apr 1, 2015·Journal of Neurochemistry·Yoon LimXin-Fu Zhou
Jul 4, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Haroon BadshahMyeong Ok Kim
Oct 7, 2015·Frontiers in Neuroscience·Lorenza RattazziFulvio D'Acquisto
Jan 23, 2016·Journal of Neurophysiology·Jasmine L Mirdamadi
Aug 15, 2017·International Review of Neurobiology·Nataliya TitovaPeter Jenner
Sep 16, 2017·Scientific Reports·Sanae Hasegawa-IshiiFumiaki Imamura
Nov 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fang-Xue Zhang, Ren-Shi Xu
Jun 2, 2018·Journal of Immunology Research·Yazmin M Flores-MartinezDaniel Martinez-Fong
Aug 17, 2018·Neurochemistry International·Lindsay Joy SpielmanAndis Klegeris
Aug 18, 2018·Molecular Neurobiology·Bruno Lima GiacobboErik F J de Vries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.