The efficacy of tacrolimus in patients with refractory dermatomyositis/polymyositis: a systematic review

Clinical Rheumatology
Yongpeng GeGuochun Wang

Abstract

The purpose of this study is to examine the efficacy and safety of tacrolimus (FK506) in the management of polymyositis (PM)/dermatomyositis (DM). The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, and China National Knowledge Infrastructure (CNKI) were searched to find articles published between May 1980 and April 2015 concerning tacrolimus therapy in PM/DM. The initial search yielded 107 articles. In the end, eight studies met our inclusion criteria and involved a total of 134 patients who received tacrolimus therapy for DM/PM. All studies were non-randomized. Oral tacrolimus of 0.075 mg/kg/day or 1.0-3.5 mg/d was administered twice daily or once daily together with glucocorticoids (GCs). According to comprehensive analysis of the studies, 93.3 % (42/45) and 64.7 % (11/17) of patients showed improvement in muscle strength and physical function status. The creatine kinase (CK) levels of 100 % (68/68) of patients decreased. The average dosage of GCs was reduced from 33.8 to 11.5 mg/day in PM/DM patients after the addition of tacrolimus. In the subject population, 65 patients had interstitial lung disease (ILD). After treatment, the forced vital capacity (FVC) and diffusing capacity for carbon monoxide...Continue Reading

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Citations

Jul 28, 2016·International Journal of Rheumatic Diseases·Ken-Ichi UenoShu-Ichi Ikeda
Apr 23, 2016·Chest·Julie MorissetJoyce S Lee
May 26, 2017·Expert Review of Respiratory Medicine·Atsushi SuzukiAryeh Fischer
Apr 11, 2018·Current Rheumatology Reports·Christopher A Mecoli, Lisa Christopher-Stine
Apr 20, 2018·Modern Rheumatology·Hirokazu Sasaki, Hitoshi Kohsaka
Jun 29, 2018·Expert Review of Clinical Immunology·Nicolò Pipitone, Carlo Salvarani
Jul 19, 2018·Current Opinion in Pulmonary Medicine·Vasileios KouranosElisabetta A Renzoni
Jul 12, 2017·Expert Review of Clinical Pharmacology·Zoltán GrigerKatalin Dankó
Sep 2, 2019·Current Rheumatology Reports·Kristen L ChenVictoria P Werth
Sep 11, 2019·Current Opinion in Rheumatology·Michela GasparottoAndrea Doria
Apr 25, 2019·Clinical Rheumatology·Ana Catarina DuarteMaria José Santos
Nov 13, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tomoyuki FujisawaTakafumi Suda
May 1, 2021·Medicina·Tomoyuki Fujisawa
May 25, 2021·Clinics in Chest Medicine·Leticia Kawano-Dourado, Joyce S Lee

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