PMID: 16638440Apr 28, 2006Paper

The efficacy of topical cyproterone acetate alcohol lotion versus placebo in the treatment of the mild to moderate acne vulgaris: a double blind study

Dermatology Online Journal
Fariba IrajiAmir Hossein Siadat

Abstract

Acne is an inflammatory condition of the pilosebaceous unit. One of the essential factors for development of acne lesions is increased sebum excretion that is promoted by androgen. It is shown that oral cyproterone acetate significantly reduces the sebum excretion. In this study we evaluated the efficacy of cyproterone acetate alcohol lotion (CAAL) in the treatment of the mild to moderate acne vulgaris. This was a randomized double-blind clinical trial performed on 86 female patients with mild to moderate acne. They were randomly divided into 3 groups and were treated with 0.5 percent CAAL (n = 30), 1 percent CAAL (n = 13) and placebo (n = 43). They were followed every 15 days for a period of 45 days. Response to treatment was evaluated by the total acne lesions counting (TLC) and acne severity index (ASI) and was analyzed statistically by SPSS program. The efficacy of treatment on TLC was maximum for 1 percent CAAL (90 % reduction in TLC)(P value = 0.000). CAAL at 0.5 percent was able to reduce TLC as high as 80.8 percent during 6 weeks followup. The efficacy of placebo was determined to be 38.5 percent. Regarding TLC, 1 percent CAAL was 2.33 times more effective than placebo. CAAL at 0.5 percent was 2.09 times more effective ...Continue Reading

Citations

Aug 13, 2011·Clinical, Cosmetic and Investigational Dermatology·Hassan AdalatkhahHomayoun Sadeghi-Bazargani
Mar 6, 2012·Seminars in Arthritis and Rheumatism·Jose Ramon ManeiroUNKNOWN BIOBADASER Study Group
Nov 11, 2008·International Journal of Pharmaceutics·Jana PardeikeRainer H Müller
Jun 27, 2009·Experimental Dermatology·Ichiro KurokawaChristos C Zouboulis
Apr 8, 2015·Dermatologic Therapy·Husein Husein-ElAhmed
Aug 8, 2014·Phytotherapy Research : PTR·Whitney A FiskRaja K Sivamani
Sep 11, 2014·Natural Product Reports·Mark S ButlerMatthew A Cooper

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