PMID: 8942885Nov 1, 1996Paper

The efficacy of topical metronidazole in the treatment of ocular rosacea

Ophthalmology
D A BarnhorstD M Meisler

Abstract

The purpose of the study is to investigate the efficacy of metronidazole topical gel in the treatment of ocular rosacea. Ten patients with ocular rosacea were treated prospectively with lid hygiene and topical metronidazole applied to the lid margin in one eye and lid hygiene alone in the fellow eye. The treatment period was 12 weeks. A masked observer graded the ocular findings at the initial visit and at the conclusion of the treatment period. Pretreatment scores were compared with post-treatment scores with respect to ocular surface, eyelid margin, and combined eyelid plus ocular surface. Eight of ten treated eyes improved, whereas only five of ten control eyes improved. There was a statistically significant improvement in the eyelid score in both the treated and control groups (P = 0.003, P = 0.025, respectively), but no significant improvement in the ocular surface score in either group. When the pretreatment and post-treatment eyelid and ocular surface scores were combined, there was a significant improvement in the treated eyes but not in the control eyes (P = 0.022, P = 0.10, respectively). No adverse effects of the metronidazole treatment were encountered in this study. Metronidazole topical gel may be a safe and effec...Continue Reading

References

Nov 1, 1990·Ophthalmology·T Hoang-XuanC S Foster

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Citations

Jun 23, 2011·The British Journal of Dermatology·E J van ZuurenZ Fedorowicz
Jun 24, 2015·The British Journal of Dermatology·E J van Zuuren, Z Fedorowicz
Dec 28, 2006·Journal of the American Academy of Dermatology·Esther J van ZuurenSally Hollis
Dec 30, 2014·Archivos de la Sociedad Española de Oftalmología·M ArrúaH Mino de Kaspar
Aug 17, 2001·Current Opinion in Ophthalmology·H G Faraj, T Hoang-Xuan
Nov 7, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C Auw-Hädrich, T Reinhard
Apr 29, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·A K Gupta, M M Chaudhry
May 18, 2012·The Cochrane Database of Systematic Reviews·Kristina LindsleyEsen K Akpek
Jul 3, 2019·Antibiotics·Azadeh Tavakoli, Judith Louise Flanagan
Nov 19, 2019·Investigative Ophthalmology & Visual Science·Xiaojin DongYusen Huang
Apr 29, 2015·The Cochrane Database of Systematic Reviews·Esther J van ZuurenLyn Charland
Jul 23, 2003·European Journal of Ophthalmology·A G Koçak-AltintasS Duman
Apr 21, 2009·Chemical Reviews·Shailendra SinghPrabhu P Mohapatra

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