PMID: 6106611Jan 1, 1980Paper

The efficacy of triazolam and chloral hydrate in geriatric insomniacs

The Journal of International Medical Research
P M PiccioneT Roth

Abstract

A double-blind crossover study was performed to evaluate the efficacy of hypnotics in geriatric insomniacs. Twenty-seven patients with a mean age of 70 years (range 60-94 years) received each of five treatments on 5 consecutive nights. The treatment conditions, consisting of chloral hydrate 250 and 500 mg, triazolam 0.25 and 0.50 mg, and placebo, were administered using a Latin Square design. Subjective estimates of sleep were collected in the morning following each treatment night. The patients' global evaluation of effectiveness indicated that triazolam 0.25 mg and 0.50 mg improved sleep more than placebo, while chloral hydrate 250 and 500 mg were not better than placebo. Triazolam 0.50 mg was felt to be significantly better than either dose of chloral hydrate. In addition, triazolam 0.50 mg was found to significantly decrease the patients' estimates of their sleep latency. Patients estimated their total sleep time to be longer following the use of triazolam 0.25 mg as compared to choral hydrate 500 mg, and their estimates of the number of awakenings was significantly lower on triazolam 0.50 mg than it was on chloral hydrate 500 mg or placebo.

References

Jan 1, 1976·The Journal of International Medical Research·T RothT Lutz
Jan 1, 1975·Psychopharmacologia·G VogelK Sexton
May 1, 1976·Social Science & Medicine·I KaracanR L Williams
Feb 1, 1974·Journal of Clinical Pharmacology·W VeldkampH V Demissianos
Feb 1, 1970·Journal of the American Geriatrics Society·K Dawson-Butterworth
Oct 26, 1963·British Medical Journal·A N EXTON-SMITHM P CURWEN
Jan 1, 1964·American Journal of Public Health and the Nation's Health·E C HAMMOND

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Citations

Jun 1, 1985·Journal of the American Geriatrics Society·D S James
Jan 1, 1984·Current Medical Research and Opinion·R BanderaS Garattini
May 1, 1983·Pharmacotherapy·T RothF J Zorick
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·P D Kroboth, R P Juhl
Jul 31, 2018·Drugs & Aging·Vivien C Abad, Christian Guilleminault
Sep 10, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Andrew D KrystalLiza H Ashbrook
Jan 1, 1982·Psychopharmacology·C L Spinweber, L C Johnson
Sep 7, 2018·Harvard Review of Psychiatry·Lauren B GerlachDonovan T Maust

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