Abstract
The treatment of onychomycosis is a challenge and infections are typically more severe and difficult to treat in toenails than in fingernails. The current study aimed to investigate the fungicidal effect of ultraviolet radiation on the growth of dermatophytes isolated from nails. Samples from patients with clinical manifestations of onychomycosis were inoculated onto Sabouraud dextrose agar and incubated at 30°C for 14 days. Isolated species were identified by specific laboratory examinations; UV-A, UV-B, and UV-C light were used to irradiate two strains of Trichophyton mentagrophytes and T. rubrum. Colony count, size and growth rate of the isolated fungi were evaluated under laboratory conditions. Trichophyton rubrum type 1 was less sensitive to UV-A and UV-C, and more sensitive to UV-B than type 2. T. mentagrophytes type 2 was slightly responsive to UV-A therapy, although no decrease in colony count was observed. Increased doses of UV-B and UV-C irradiation decreased the counts. The effect of radiation on colony size was dependent on the dose and type of irradiation. UV-A, UV-B, and UV-C light seem to be effective in decreasing colony growth of the most prevalent fungi, which caused onychomycosis in the current study samples....Continue Reading
References
Jun 1, 1985·Applied and Environmental Microbiology·J C ChangJ D Johnson
May 1, 1995·Mycoses·J Brasch, A Menz
Feb 3, 1998·Journal of the American Academy of Dermatology·M KerscherP Altmeyer
Jul 25, 2000·Journal of the American Academy of Dermatology·A K GuptaR C Summerbell
Sep 27, 2000·Journal of the American Academy of Dermatology·M A GhannoumB Elewski
Dec 7, 2000·Journal of the American Podiatric Medical Association·A K Gupta, W S Joseph
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·J L RavanatJ Cadet
Mar 7, 2003·Applied and Environmental Microbiology·Kevin A HughesKevin K Newsham
Jul 23, 2003·Mycoses·J BraschE Christophers
Mar 20, 2004·The British Journal of Dermatology·A K GuptaA M Johnson
Jul 13, 2004·Photochemistry and Photobiology·Threes G M SmijsHans J Schuitmaker
May 11, 2005·Mycopathologia·Zulal ErbagciIclal Balci
Dec 22, 2005·Mycoses·J Brasch, C Kay
May 15, 2009·The New England Journal of Medicine·David de Berker
Aug 8, 2009·Journal of Applied Microbiology·C SantosN Lima
May 19, 2010·Journal of the American Podiatric Medical Association·Adam S LandsmanEric S Bornstein
Feb 22, 2012·Expert Review of Anti-infective Therapy·Tianhong DaiMichael R Hamblin
May 17, 2012·Medical Mycology·Ali Rezaei-MatehkolaeiHossein Mirhendi
Jul 27, 2012·BMJ : British Medical Journal·Mathieu BoniolSara Gandini
Citations
Oct 6, 2016·Medical Mycology·Tamara AngeloTais Gratieri
Jul 13, 2019·F1000Research·Aditya K Gupta, Nadia Stec
Aug 22, 2018·Journal of Fungi·Roderick Hay
Jul 10, 2019·Applied and Environmental Microbiology·Solange TorresJaime R Cabrera-Pardo
Apr 4, 2021·The Ocular Surface·Sanjay MarasiniJennifer P Craig