The efficacy of vitamin D in multiple sclerosis: A meta-analysis

Multiple Sclerosis and Related Disorders
Chao ZhengTao Jin

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelination disorder in the central nervous system (CNS) leading to a high level of neurological disability. The pathogenesis of MS remains largely unknown, which explains the lack of significant efficacy of therapy in MS. Vitamin D deficiency is widely considered to be an environmental risk factor for MS. Many studies investigating the therapeutic effects of vitamin D on MS have been applied. The objective of this systematic review and meta-analysis was to evaluate the effectiveness of vitamin D in MS patients. To obtain a more comprehensive estimate of the efficacy of vitamin D on MS patients, we conducted a meta-analysis to determine the role of vitamin D in MS. The PubMed, EMBASE and Cochrane databases were searched in October 2017. Randomized, double-blind, placebo-controlled clinical trials recorded within the three main databases were considered. The analysis was conducted for two specific outcomes: Expanded Disability Status Scale (EDSS) score and annual relapse rate (ARR). Vitamin D3 as add-on treatment had no significant therapeutic effect on MS according to EDSS score (mean difference -0.01 [95% CI -0.34 to 0.33]). The ARR was higher in the vitamin D group than in t...Continue Reading

Citations

Sep 25, 2018·The Cochrane Database of Systematic Reviews·Vanitha A JagannathSarah A Robinson
Oct 15, 2018·Acta Neurologica Scandinavica·Trygve HolmøyMargitta T Kampman
Mar 17, 2019·International Journal of Molecular Sciences·Monika BerezowskaHelen Dawes
Oct 26, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Julia FeigeJohann Sellner
Jul 16, 2020·British Journal of Pharmacology·Wei Zhen YehHelmut Butzkueven
Apr 17, 2020·Brain Sciences·Marina Kleopatra BozikiNikolaos Grigoriadis
Aug 9, 2019·Annals of Clinical and Translational Neurology·Emmanuelle WaubantAnnette Langer-Gould
Feb 6, 2021·Multiple Sclerosis and Related Disorders·Steve Simpson-YapGeorge Jelinek
Mar 7, 2021·International Journal of Molecular Sciences·Luiza Ayumi Nishiyama MimuraAlexandrina Sartori
Mar 13, 2021·Current Opinion in Neurology·Sarah B SimmonsDaniel Ontaneda
Jun 2, 2021·Expert Review of Neurotherapeutics·Robin BoltjesJan Damoiseaux
Jun 15, 2021·Multiple Sclerosis and Related Disorders·Miri ElgabsiGal Ifergane
Aug 4, 2021·Survey of Ophthalmology·Shani Pillar, Radgonde Amer

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