The efficacy of vitamin E against oxidative damage and autoantibody production in systemic lupus erythematosus: a preliminary study

Clinical Rheumatology
Etsuko MaeshimaMasatoshi Mune

Abstract

The hypothesis that reactive oxygen species (ROS) modification of DNA is involved in the development of autoantibodies in systemic lupus erythematosus (SLE) is supported by the enhanced reactivity of anti-DNA antibodies to ROS-denatured DNA. We studied the efficacy of vitamin E against both oxidative DNA damage and autoantibody production in SLE. Urinary 8-hydroxydeoxyguanosine (8-OHdG), an indicator of oxidative DNA damage, and the anti-double-stranded DNA (anti-ds DNA) antibody, a predictor of disease activity, were assayed twice, first during the season with the most intense sunlight and then later in the year. Twelve women among 36 outpatients received vitamin E (150 to 300 mg/day) together with prednisolone (PSL). No significant age or daily dose of PSL differences were evident between patient groups. Urinary 8-OHdG in the PSL with vitamin E group (15.0 +/- 10.2 ng/mg during the period of intense sunlight and 11.7 +/- 8.7 ng/mg during the remainder of the year) did not differ significantly from that in the PSL without vitamin E group (20.0 +/- 23.2 and 11.0 +/- 5.9 ng/mg, at these respective times), but the anti-ds DNA antibody titer in the PSL with vitamin E group (17.9 +/- 20.3 IU/l during the period of intense sunlight ...Continue Reading

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Citations

Nov 1, 2011·Autoimmunity Reviews·Jacob Orme, Chandra Mohan
Aug 12, 2008·Autoimmunity Reviews·Eyal ZifmanYehuda Shoenfeld
Jan 12, 2011·Rheumatic Diseases Clinics of North America·Anan J Haija, Steffan W Schulz
Mar 16, 2017·Nutrition Research Reviews·Marina Aparicio-SotoCatalina Alarcón-de-la-Lastra
Jun 10, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tsukasa NakamuraHikaru Koide
Sep 15, 2012·QJM : Monthly Journal of the Association of Physicians·W-F NgJ L Newton
Nov 22, 2016·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Biji Theyilamannil KurienRobert Hal Scofield

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