PMID: 9547117Apr 18, 1998Paper

The efficacy, safety and tolerability of antidepressants in late life depression: a meta-analysis

Journal of Affective Disorders
N MittmannN H Shear

Abstract

To determine the efficacy, safety and tolerability of antidepressants in depressed elderly patients. Search for randomized controlled double-blind studies evaluating atypical antidepressants (ATYPs), reversible inhibitors of monoamine oxidase-A, selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants in moderate/severe depressed patients > or = 60 years for > or = four weeks. The random effects model (single-arm; comparative) was used to aggregate efficacy, safety and dropout. No difference in single-arm aggregation of outcomes for four antidepressant classes. Comparative analyses showed no statistical difference between outcomes, except SSRIs had a higher response rate than ATYPs. Elderly show no differences in antidepressant class outcomes. Heterogeneity and lack of power. There is little advantage for antidepressant classes over another in the aged.

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