The Efficiency and Safety of Intrarectal Topical Anesthesia for Transrectal Ultrasound-Guided Prostate Biopsy: A Systematic Review and Meta-Analysis

Urologia Internationalis
Yubo YangPing Han

Abstract

The study aims to review the current evidence to determine the efficiency and safety of intrarectal topical anesthesia (ITA) for transrectal ultrasound-guided prostate biopsy. A comprehensive search of the literature was performed using Medline, Embase and Cochrane central register of controlled trials. All randomized controlled trials (RCTs) comparing the efficacy and safety of periprostatic nerve block (PNB), ITA, and PNB combined with ITA were included. The mean pain scores after the biopsy procedure, the mean pain scores after the probe insertion and adverse events were evaluated. Thirty-2 RCTs were identified in the meta-analysis. ITA could significantly reduce pain during probe insertion compared to control and placebo. The PNB group had less pain after the prostate biopsy than the ITA group. PNB combined with ITA could significantly reduce pain during the biopsy procedure compared to ITA alone. No significant differences were found in adverse events in ITA versus control, ITA versus placebo, and ITA versus PNB. ITA could reduce pain after probe insertion and pain after biopsy although it was inferior to PNB in reducing pain during prostate biopsy. ITA combined with PNB was more effective than ITA alone. In addition, it w...Continue Reading

Associated Clinical Trials

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Aug 15, 2002·BJU International·N N K LynnP H O'Reilly
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology·Hülya BaşarErtan Batislam
Oct 18, 2005·BJU International·Klaus G FinkNikolaus T Schmeller
May 3, 2006·International Braz J Urol : Official Journal of the Brazilian Society of Urology·M Tobias-MachadoEric R Wroclawski
Jul 13, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Seung-Hun SongChoung-Soo Kim
Jan 11, 2007·Prostate Cancer and Prostatic Diseases·H Y TiongK Esuvaranathan

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Citations

Mar 28, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Abdullah DemirtaşTürev Demirtaş
Dec 7, 2018·European Urology Focus·Adrian PilatzBenjamin Pradere

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