The efficiency of peptide immunotherapy for respiratory allergy

Expert Review of Clinical Pharmacology
Cristoforo IncorvaiaErminia Ridolo

Abstract

Allergen immunotherapy (AIT) was introduced more than a century ago and is yet the only disease-modifying treatment for allergy. AIT is currently conducted with whole allergen extracts and several studies clearly support its efficacy in the treatment of respiratory allergies, however the need for a long treatment - that affects costs and patients compliance - and possible IgE-mediated adverse events are still unresolved issues. Peptide immunotherapy is based on the use of short synthetic peptides which represent major T-cell epitopes of the allergen with markedly reduced ability to cross-link IgE and activate mast cells and basophils. Data from clinical trials confirmed the efficacy and tolerability of peptide immunotherapy in patients with cat allergy, with a sustained clinical effect after a short course treatment. Peptide therapy is a promising safe and effective new specific treatment for allergy to be developed for the most important allergens causing rhinitis or asthma.

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Citations

Nov 30, 2018·Expert Review of Clinical Immunology·Agnes Sze Yin LeungGary Wing Kin Wong
Aug 20, 2017·Current Allergy and Asthma Reports·Hardik D PatelMeera R Gupta
Feb 7, 2018·Expert Review of Clinical Immunology·Farnaz Tabatabaian, Thomas B Casale

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