The elastic lamellae of devitalized arteries calcify when incubated in serum: evidence for a serum calcification factor

Arteriosclerosis, Thrombosis, and Vascular Biology
Paul A PriceMatthew K Williamson

Abstract

To determine whether serum contains an activity that induces artery calcification. The elastic lamellae of devitalized rat aortas calcify rapidly in rat or bovine serum, or in human serum provided [Pi] > or =2 mmol/L. This calcification is attributable to a potent serum calcification factor (SCF), one that causes devitalized aortas to calcify when incubated in DMEM containing as little as 1.5% serum but not in DMEM alone. The SCF that initiates medial elastin calcification has the same 50- to 150-kDa size and protease sensitivity as the SCF shown previously to initiate calcification of type I collagen. Our working hypothesis is that the same SCF initiates calcification of collagen and elastin, and that this SCF arises from sites of normal bone mineralization and, like alkaline phosphatase, is released into general circulation. The SCF does not initiate medial elastin calcification in living arteries, which suggests that vascular cells may prevent this calcification. This hypothesis is supported by the observations that living arteries secrete the calcification inhibitor matrix Gla protein (MGP); that inactivation of MGP with warfarin causes living arteries to calcify; and that addition of MGP to medium containing warfarin preve...Continue Reading

References

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Citations

Dec 22, 2007·Calcified Tissue International·Damon Toroian, Paul A Price
Nov 30, 2006·Journal of Thrombosis and Thrombolysis·Richard C Becker
Jul 28, 2009·Current Osteoporosis Reports·Linda L Demer, Yin Tintut
Oct 4, 2006·Nephrology·Diane Proudfoot, Catherine M Shanahan
May 21, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Su ShaoDwight A Towler
Oct 29, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Kelly E BeazleyMaria V Nurminskaya
Sep 24, 2010·Kidney International·W Charles O'Neill, Koba A Lomashvili
Feb 9, 2007·Kidney International·W C O'Neill
Mar 29, 2014·Molecular Nutrition & Food Research·Brecht A G WillemsLeon J Schurgers
Aug 6, 2009·Clinical and Experimental Nephrology·Sachiko MuneTakashi Shigematsu
Apr 8, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Su ShaoDwight A Towler
Oct 13, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Ziyad Al-AlyDwight A Towler
Aug 29, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Dealba GheduzziIvonne Pasquali Ronchetti
Oct 2, 2008·Journal of Thrombosis and Haemostasis : JTH·R LemmensV Thijs
Mar 25, 2020·Biological Reviews of the Cambridge Philosophical Society·Jian-Fei YanKai Jiao
Feb 8, 2011·Clinical Cardiology·Chandrasekar PalaniswamyStephen J Peterson
Jul 6, 2020·Archives of Physiology and Biochemistry·Neshe Ferahova Nazifova-TasinovaBistra Tzaneva Galunska

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