The electric field distribution in the brain during TTFields therapy and its dependence on tissue dielectric properties and anatomy: a computational study

Physics in Medicine and Biology
Cornelia WengerPedro C Miranda

Abstract

Tumor treating fields (TTFields) are a non-invasive, anti-mitotic and approved treatment for recurrent glioblastoma multiforme (GBM) patients. In vitro studies have shown that inhibition of cell division in glioma is achieved when the applied alternating electric field has a frequency in the range of 200 kHz and an amplitude of 1-3 V cm(-1). Our aim is to calculate the electric field distribution in the brain during TTFields therapy and to investigate the dependence of these predictions on the heterogeneous, anisotropic dielectric properties used in the computational model. A realistic head model was developed by segmenting MR images and by incorporating anisotropic conductivity values for the brain tissues. The finite element method (FEM) was used to solve for the electric potential within a volume mesh that consisted of the head tissues, a virtual lesion with an active tumour shell surrounding a necrotic core, and the transducer arrays. The induced electric field distribution is highly non-uniform. Average field strength values are slightly higher in the tumour when incorporating anisotropy, by about 10% or less. A sensitivity analysis with respect to the conductivity and permittivity of head tissues shows a variation in fiel...Continue Reading

References

Mar 1, 1976·Medical & Biological Engineering·T Yamamoto, Y Yamamoto
Nov 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Y LuJ Yu
May 1, 1992·IEEE Transactions on Bio-medical Engineering·G De Mercato, F J Garcia Sanchez
Apr 1, 1988·IEEE Transactions on Bio-medical Engineering·A J SurowiecA Swarup
Dec 1, 1967·The Bulletin of Mathematical Biophysics·R Plonsey, D B Heppner
Nov 1, 1984·IEEE Transactions on Bio-medical Engineering·R PelosoR K Jain
Mar 1, 1984·IEEE Transactions on Bio-medical Engineering·G N Reddy, S Saha
Feb 1, 1983·IEEE Transactions on Bio-medical Engineering·J D KosterichS R Pollack
Apr 1, 1982·Physics in Medicine and Biology·R D StoyH P Schwan
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Mar 1, 1997·IEEE Transactions on Bio-medical Engineering·S B BaumannF M Meno
Jun 23, 2001·Physics in Medicine and Biology·J LatikkaH Eskola
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·D S TuchJ W Belliveau
Jun 5, 2002·Medical Image Analysis·David W Shattuck, Richard M Leahy
Jun 1, 1955·Journal of Cellular Physiology·W H FREYGANG, W M LANDAU
Feb 1, 1963·Experimental Neurology·J B RANCK
Jul 1, 1963·The American Journal of Physiology·A VAN HARREVELDK W NOBEL
May 6, 2004·Cancer Research·Eilon D KirsonYoram Palti
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Eilon D KirsonYoram Palti
Jul 29, 2009·Physics in Medicine and Biology·C GabrielE H Grant
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
May 23, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Roger StuppPhilip H Gutin
Jun 20, 2012·Expert Review of Neurotherapeutics·Ekokobe Fonkem, Eric T Wong
Oct 9, 2012·Computer Methods and Programs in Biomedicine·Salman ShahidTony Ahfock
Jan 1, 2013·NeuroImage·Pedro Cavaleiro MirandaGiulio Ruffini
Nov 29, 2013·Journal of Biomedical Research·Michael J RussellDavid F Wiley
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Philip H Gutin, Eric T Wong
Jul 9, 2014·Physics in Medicine and Biology·Pedro C MirandaPeter J Basser
Apr 23, 2015·PloS One·Maria Ida IaconoLeonardo M Angelone

❮ Previous
Next ❯

Citations

Feb 18, 2016·International Journal of Radiation Oncology, Biology, Physics·Cornelia WengerPedro C Miranda
Sep 25, 2016·Neuro-oncology·Andreas F HottingerRoger Stupp
Jul 12, 2018·IEEE Reviews in Biomedical Engineering·Cornelia WengerAnders R Korshoej
Jan 15, 2019·Physics in Medicine and Biology·Anders Rosendal KorshoejAxel Thielscher
Dec 20, 2018·Oncotarget·Joshua BranterStuart Smith
Aug 24, 2017·American Journal of Clinical Oncology·Stuart H BurriMinesh P Mehta
Aug 1, 2020·CNS Neuroscience & Therapeutics·Hao WuLing Chen
Oct 13, 2017·Physics in Medicine and Biology·Joshua J TimmonsEric T Wong
May 10, 2018·Scientific Reports·Andrea R Di SebastianoMatthew O Hebb
May 6, 2019·Brain Topography·Hannah McCannLeandro Beltrachini
Aug 1, 2020·Current Treatment Options in Oncology·Ashley P GhiaseddinDavid D Tran
Aug 3, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elijah J MunDaniel D Von Hoff
Nov 21, 2020·Frontiers in Oncology·Francesca A CarrieriPhuoc T Tran
Oct 25, 2020·Cancers·Michaela GriffinStuart Smith
Dec 27, 2019·NeuroImage·Konstantin WeiseThomas R Knösche
Apr 30, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Peter WustPirus Ghadjar
Jul 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shiyu LiuXin Jiang
Jul 23, 2021·Advanced Science·Elise P W JenkinsGeorge G Malliaras
Aug 20, 2021·Advances in Radiation Oncology·Edwin LokEric T Wong
Aug 21, 2020·Computer Methods and Programs in Biomedicine·Nichal Gentilal, Pedro Cavaleiro Miranda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Ricardo SalvadorPedro C Miranda
Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Moshe GiladiYoram Palti
© 2021 Meta ULC. All rights reserved