PMID: 8592657Nov 1, 1995Paper

The electrical characteristics of human skin in vivo

Pharmaceutical Research
Y N Kalia, R H Guy

Abstract

The objectives of this study were to investigate the impedance properties of human skin in vivo and to examine the effect of iontophoresis upon them. Having established the intra- and inter-individual variation in basal values of skin impedance, the effect of varying iontophoretic current density, ionic strength and counter-ion on the rate of recovery of skin impedance after iontophoresis was investigated. Passage of an iontophoretic current caused a significant reduction in the magnitude of the skin impedance. Increasing the current density caused an even greater reduction in the value of the skin impedance and slowed the rate of recovery. Reduction of the ionic strength resulted in an increase in the rate of recovery following iontophoresis. A significant increase in the rate of recovery was observed when CaCl2 replaced NaCl as the electrolyte. Although visual inspection revealed the presence of greater erythema when CaCl2 was used, there was an absence of the mild sensation experienced by volunteers when using NaCl. The last part of the study established a correlation between transepidermal water loss and impedance analysis as complementary methods for probing skin barrier function in vivo. The data were fitted to an equival...Continue Reading

Associated Clinical Trials

Aug 17, 2018·Hernán Andrés de la Barra OrtizHernán Andrés de la Barra Ortiz

Citations

Sep 19, 2006·Forschende Komplementärmedizin = Research in Complementary Medicine·Bernhard WiegeleDominik Irnich
Dec 16, 2006·Journal of Cosmetic Dermatology·Mahesh N PadamwarK R Mahadik
Nov 22, 2001·Annals of Plastic Surgery·K Islamoglu, E Ozgentas
Nov 1, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Narayanasamy Kanikkannan
Jul 18, 2003·AAPS PharmSci·Mohammad Al-KhaliliBozena B Michniak
Jul 11, 2006·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Renzo LambrechtAndré O Barel
Nov 19, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Mohammad HabibiDavid P Klemer
Nov 30, 2000·Medical & Biological Engineering & Computing·E F ProkhorovG Zaldivar Lelo de Larrea
Jul 2, 2005·Expert Opinion on Investigational Drugs·G Cevc
May 15, 2020·IET Systems Biology·Dhruba Jyoti Bora, Rajdeep Dasgupta
Nov 1, 1996·Medical & Biological Engineering & Computing·E T McAdamsF Risacher
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·R H Guy
Jun 29, 2001·The Journal of Pharmacy and Pharmacology·C CurdyR H Guy
Feb 24, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y TakahashiY Machida
Jun 26, 2002·Biological & Pharmaceutical Bulletin·Makoto KanebakoKozo Takayama
Oct 24, 2020·IET Systems Biology·Dhruba Jyoti Bora, Rajdeep Dasgupta
Mar 4, 1999·International Journal of Pharmaceutics·A K BangaT K Ghosh
Apr 3, 1999·Journal of Pharmaceutical Sciences·Y N KaliaR H Guy
May 20, 1998·Dermatologic Clinics·Y N KaliaR H Guy
Mar 24, 2007·The Journal of Investigative Dermatology·Biancamaria BaroliM Arturo López-Quintela
May 30, 2021·Advanced Healthcare Materials·Mengjia ZhuYingying Zhang

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