The electroretinogram and visual evoked potential of freely moving rats

Brain Research Bulletin
O Szabó-SalfayG Juhász

Abstract

The vascularised rat retina could be one of the most useful experimental objects in visual neuroscience to understand human visual physiological and pathological processes. We report here on a new method of implantation for studying the visual system of freely moving rats that provides a rat model for simultaneous recording at corneal and cortical level and is stable enough to record for months. We implanted light emitting diodes onto the skull behind the eyeball to stimulate the eye with flashes and to light adapt the retina with constant light levels. A multistrand, stainless steel, flexible fine wire electrode placed on the eyeball was used for electroretinogram recording and screw electrodes (left/right visual and parietal cortical) were used to record the visual evoked potential and the electroencephalogram. In the present report we focus on the new method of implantation for recording the corneal flash electroretinogram of normal, freely moving rats simultaneously with the visual evoked cortical potential showing examples in various visual experiments. We also introduce a program for retinogram and visual evoked potential analysis, which defines various measures (latencies, areas, amplitudes, and durations) and draw atten...Continue Reading

References

Aug 1, 1979·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·C RaittaM Naukkarinen
Jan 1, 1991·Free Radical Biology & Medicine·D Armstrong, F al-Awadi
Nov 1, 1990·The Journal of Toxicological Sciences·R ImaiS Sato
Jan 1, 1990·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·P A GoodD R Blake
Jan 1, 1986·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C TashiroI Yoshiya
Jan 1, 1982·Vision Research·R W Nygaard, T E Frumkes
Nov 1, 1982·Journal of Pharmacological Methods·S SatoS Chiba
Jan 1, 1995·Documenta Ophthalmologica. Advances in Ophthalmology·M F Marmor, E Zrenner
Jun 2, 1998·Electroencephalography and Clinical Neurophysiology·H K MeerenA M Coenen
Jun 19, 1998·Neuroreport·I AbrahámG Juhász
May 27, 1999·Vision Research·D G Green, N V Kapousta-Bruneau
Jan 14, 2000·Journal of Neuroscience Methods·E A Newman, R Bartosch
Aug 18, 2000·Survey of Ophthalmology·H P Scholl, E Zrenner
Mar 29, 2001·Journal of Neuroscience Methods·J PálhalmiG Juhász
Oct 1, 1956·Journal of the Optical Society of America·M ALPERN, J J FARIS

❮ Previous
Next ❯

Citations

Jan 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Antti Valjakka
May 18, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Robert GalambosNora Szilágyi
Sep 13, 2008·The International Journal of Neuroscience·Magor L LörinczGábor Juhász
Sep 15, 2007·Journal of Neurochemistry·Andrea M PappGábor Juhász
Mar 31, 2015·Restorative Neurology and Neuroscience·Elena G SergeevaBernhard A Sabel
Mar 8, 2006·Neurochemistry International·Agnes SimonJulianna Kardos
May 9, 2015·Anesthesiology·Anthony G HudetzKristina M Ropella
Feb 9, 2017·Pharmacology & Therapeutics·Christine T O NguyenMagnus Ivarsson
Feb 2, 2010·Journal of the Experimental Analysis of Behavior·Eunjeong LeeCyriel M A Pennartz
Aug 22, 2020·Veterinary Ophthalmology·Angélica M V SafatlePaula Y Sacai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.