PMID: 11906664Mar 22, 2002Paper

The electroretinographic phenotype of dogs with Golden Retriever muscular dystrophy

Veterinary Ophthalmology
W A BeltranB Clerc

Abstract

To characterize the flash electroretinogram (ERG) in the Golden Retriever muscular dystrophy (GRMD) dog and to compare the results with those from a control group of Golden Retrievers. To investigate whether similar abnormalities of the ERG as those found in a majority of human patients with Duchenne muscular dystrophy (DMD) are also observed in the GRMD dog, the canine model for DMD. Animals Five GRMD dogs and five age-matched clinically normal Golden Retrievers. An ophthalmic examination was carried out prior to performing electroretinography under general anesthesia. Rod, combined rod-cone and oscillatory potentials responses were recorded after dark adaptation. Responses to 30-Hz-flicker were recorded after light adaptation. The ERG responses of the GRMD dogs were compared with those of the control dogs by use of a Wilcoxon signed rank test. GRMD dogs had significantly reduced a and b-wave amplitudes after dim white flash stimuli (rod response) and reduced a-wave amplitude after bright white flash stimuli (rod-cone response). The ERG abnormalities observed in the GRMD dog suggest a dysfunction in the rod signaling pathway. These ERG alterations are different from those observed in human patients with DMD.

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Citations

Jan 13, 2005·Veterinary Ophthalmology·Mary E LassalineGary W Ellison
Apr 25, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H S Cho, N Y Park

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