The elementome of calcium-based urinary stones and its role in urolithiasis

Nature Reviews. Urology
Krishna RamaswamyMarshall L Stoller

Abstract

Urolithiasis affects around 10% of the US population with an increasing rate of prevalence, recurrence and penetrance. The causes for the formation of most urinary calculi remain poorly understood, but obtaining the chemical composition of these stones might help identify key aspects of this process and new targets for treatment. The majority of urinary stones are composed of calcium that is complexed in a crystalline matrix with organic and inorganic components. Surprisingly, mitigation of urolithiasis risk by altering calcium homeostasis has not been very effective. Thus, studies to identify other therapeutic stone-specific targets, using proteomics, metabolomics and microscopy techniques, have been conducted, revealing a high level of complexity. The data suggest that numerous metals other than calcium and many nonmetals are present within calculi at measurable levels and several have distinct distribution patterns. Manipulation of the levels of some of these elemental components of calcium-based stones has resulted in clinically beneficial changes in stone chemistry and rate of stone formation. The elementome--the full spectrum of elemental content--of calcium-based urinary calculi is emerging as a new concept in stone rese...Continue Reading

References

Dec 1, 1979·Urological Research·R ScottJ M Ottoway
May 1, 1978·Kidney International·H Fleisch
Jan 1, 1978·European Urology·A Desjardins, R Tawashi
Apr 2, 1976·Science·A Kappas, M D Maines
Oct 15, 1992·The New England Journal of Medicine·F L CoeJ R Asplin
Jan 1, 1990·International Urology and Nephrology·K KomlehP P Singh
Jan 1, 1986·Urologia Internationalis·F S Haddad, A Kouyoumdjian
Feb 1, 1988·British Journal of Urology·K KohriN J Blacklock
Jun 1, 1988·British Journal of Urology·M A Wandt, L G Underhill
Apr 1, 1987·The Journal of Nutrition·R M Leach, C V Gay
Jan 1, 1987·European Urology·J Joost, R Tessadri
Apr 1, 1986·The Science of the Total Environment·M EspositoM Oddone
Nov 1, 1985·British Journal of Industrial Medicine·C G ElinderO Vesterberg
Aug 24, 1968·Lancet·D G OreopoulosM G McGeown
Apr 1, 1969·Physiological Reviews·W Mertz
Jul 1, 1982·Nutrition Reviews·E M Carlisle
Jan 1, 1982·Journal of the American College of Nutrition·G JohanssonB Wikström
Sep 1, 1982·Kidney International·F P MuldowneyM F Moloney
May 1, 1995·Nutrition Reviews·L K Massey, S J Whiting
Sep 1, 1994·The American Journal of Clinical Nutrition·W J BurtisA E Broadus
Jan 1, 1993·Urological Research·K HöbarthJ Hofbauer
Mar 25, 1993·The New England Journal of Medicine·G C CurhanM J Stampfer
Dec 24, 1997·Critical Reviews in Clinical Laboratory Sciences·J L Greger, J E Sutherland
May 20, 1998·The American Journal of Clinical Nutrition·J R Turnlund
Jun 25, 1998·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·M BenderdourF Belleville

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Citations

Oct 25, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·D BazinM Daudon
Nov 28, 2016·The Journal of Urology·Gregory E TasianSusan L Furth
Feb 3, 2018·The Journal of Urology·Pietro Manuel FerraroEric N Taylor
Mar 6, 2018·Urolithiasis·Muhammed A P ManzoorPunchappady-Devasya Rekha
Sep 23, 2018·Scientific Reports·Sunita P HoMarshall L Stoller
Oct 11, 2020·Biological Trace Element Research·Abdallah A ShaltoutRoshdi Seoudi
Nov 20, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Paula PongracCharlotte Poschenrieder
Nov 19, 2020·Anais Da Academia Brasileira De Ciências·Uzma SaleemBashir Ahmad
Mar 13, 2021·Therapeutic Advances in Urology·Derry Minyao NgQi Ma
Apr 20, 2021·Heliyon·Iván PachecoJosé de la Fuente
Jun 26, 2021·Urologia·Andrea PanunzioMaria Angela Cerruto

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