The elimination of equine strongyles and hematological and pathological consequences following larvicidal doses of thiabendazole

Veterinary Parasitology
S M HopferW H Daniels

Abstract

Twelve horses were divided into three groups and given various doses of a mixed species strongyle inoculum, representing light, moderate, and heavy infections. Three weeks after the larval inoculations, three animals from each group were given larvicidal doses of thiabendazole (TBZ) (440 mg kg-1 on two consecutive days); one animal from each group served as a non-medicated control. Treatment was repeated three weeks later. One treated animal from each group was designated for long-term study; others were necropsied to study adult and larval parasite loads. Six of the twelve animals with strongylosis developed moderate eosinophilia. TBZ given at 440 mg kg-1 on two consecutive days caused depression, lethargy, and anorexia which lasted for five days. Eosinopenia, lymphopenia, and neutrophilia occurred in treated animals, and lasted for three days. During the course of TBZ treatment, one horse died from what appeared to be a mis-dosing or an anaphylactic reaction. At necropsy, active thrombi of the anterior mesenteric artery were seen in parasitized animals, but not in those treated with TBZ. Five out of seven medicated horses were completely free of adult and larval strongyle parasites. One had a few Strongylus edentatus larvae a...Continue Reading

References

Dec 1, 1977·New Zealand Veterinary Journal·P Scott
Jul 1, 1977·Equine Veterinary Journal·J L DuncanN K Preston
Jan 1, 1978·Equine Veterinary Journal·D G McBeathJ L Duncan
Jan 1, 1971·Equine Veterinary Journal·M C Round
Jul 13, 1974·The Veterinary Record·J L Duncan
Apr 1, 1957·Journal of Comparative Pathology·R K ARCHER, D POYNTER

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Citations

Apr 13, 2005·American Journal of Veterinary Research·Rebecca S McConnicoRustin M Moore

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