The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea

Tropical Medicine & International Health : TM & IH
Pere SimarroJean Jannin

Abstract

After the resurgence of sleeping sickness in Luba, Equatorial Guinea, a major campaign to control the disease was established in 1985. The campaign comprised no vector control, but intensive active and passive surveillance using serology for screening, and treatment of all parasitological and suspected serological cases. Total prevalence was used to classify villages as endemic, at risk, anecdotal and non-endemic which also allowed defining the geographic extent of the focus. Active case-finding was implemented from 1985 to 2004. The frequency of surveys was based on parasitological prevalence: twice a year during intensified control, once a year during ordinary control and once every 2 years during the control consolidation phase, when the parasitological prevalence in the whole focus fell to 0.1%. From 1985 to 1999, the indirect immunofluorescent antibody test (IFAT) was used as an initial screening tool, followed by parasitological confirmation of IFAT positive cases, and the Card Agglutination Trypanosomiasis Test (CATT) if necessary. In 2000, the IFAT was replaced by the CATT. Serum-positive individuals without parasitological confirmation were subsequently tested on serial dilution. All cases underwent lumbar puncture to ...Continue Reading

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Citations

Oct 12, 2010·Clinical Microbiology Reviews·J L N BarrattD Stark
Sep 1, 2007·International Journal of Health Geographics·Jorge CanoJesus Roche
Nov 3, 2010·International Journal of Health Geographics·Pere P SimarroJean G Jannin
Dec 17, 2011·Emerging Infectious Diseases·Pere P SimarroJean G Jannin
Jan 21, 2014·Parasites & Vectors·Carlos Cordon-ObrasJean-Mathieu Bart
Nov 1, 2015·Parasitology International·Samson Muuo NzouSatoshi Kaneko
Mar 27, 2009·Tropical Medicine & International Health : TM & IH·C Cordon-ObrasJ Cano
Feb 20, 2015·Tropical Medicine & International Health : TM & IH·Peter SteinmannFabrizio Tediosi
Sep 23, 2016·PLoS Computational Biology·Harwin de VriesJoris van de Klundert
May 23, 2017·PLoS Neglected Tropical Diseases·José R FrancoDaniel Argaw

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