The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16

The Journal of Pharmacology and Experimental Therapeutics
Ana Ramírez de MolinaGuillermo Reglero

Abstract

Ellagic acid (EA) and some derivatives have been reported to inhibit cancer cell proliferation, induce cell cycle arrest, and modulate some important cellular processes related to cancer. This study aimed to identify possible structure-activity relationships of EA and some in vivo derivatives in their antiproliferative effect on both human colon cancer and normal cells, and to compare this activity with that of other polyphenols. Our results showed that 4,4'-di-O-methylellagic acid (4,4'-DiOMEA) was the most effective compound in the inhibition of colon cancer cell proliferation. 4,4'-DiOMEA was 13-fold more effective than other compounds of the same family. In addition, 4,4'-DiOMEA was very active against colon cancer cells resistant to the chemotherapeutic agent 5-fluoracil, whereas no effect was observed in nonmalignant colon cells. Moreover, no correlation between antiproliferative and antioxidant activities was found, further supporting that structure differences might result in dissimilar molecular targets involved in their differential effects. Finally, microarray analysis revealed that 4,4'-DiOMEA modulated Wnt signaling, which might be involved in the potential antitumor action of this compound. Our results suggest tha...Continue Reading

References

Dec 14, 2004·The Journal of Nutritional Biochemistry·Jack N LossoRobert Truax
Apr 13, 2005·Biochemical and Biophysical Research Communications·Ki Suk JeonHo Jeong Kwon
Mar 28, 2006·Biochemical Pharmacology·Bharat B Aggarwal, Shishir Shishodia
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Jun 19, 2007·Seminars in Cancer Biology·Gary D StonerJohn F Lechner
Feb 13, 2008·Archives of Biochemistry and Biophysics·Laure PoquetGary Williamson
Feb 26, 2008·The International Journal of Biochemistry & Cell Biology·Ana Ramírez de MolinaJuan Carlos Lacal
Aug 23, 2008·Toxicon : Official Journal of the International Society on Toxinology·Saulo L Da SilvaSérgio Marangoni
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning ZhangWei-Shan Chen
May 14, 2009·Molecular Nutrition & Food Research·Antonio González-SarríasMaría-Teresa García-Conesa
Dec 18, 2009·Journal of Agricultural and Food Chemistry·Meenakshi SharmaNavindra P Seeram
Feb 2, 2010·Journal of Agricultural and Food Chemistry·Sashi G KasimsettyDaneel Ferreira
Sep 15, 2010·Molecular Aspects of Medicine·Mar LarrosaFrancisco A Tomás-Barberán
Aug 11, 2011·Mutation Research·Franziska FerkSiegfried Knasmüller
Oct 7, 2011·Journal of Oncology·William W LiAlbert S Chiou
Feb 4, 2012·Journal of Zhejiang University. Science. B·Wu-yang HuangChun-yang Li
Sep 4, 2012·Biotechnology Advances·Isis S SantosEliana B Souto
Mar 28, 2013·Nutrition and Cancer·Armando Del Follo-MartinezSusanne Mertens-Talcott
Apr 6, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Margarita González-VallinasAna Ramírez de Molina
Jun 20, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Juan Carlos EspínFrancisco Tomás-Barberán
Jul 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhenpeng QiuFan Zhu
Jul 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan-Chiang ChungChih-Ping Hsu
Sep 17, 2013·Nutrition Reviews·Margarita González-VallinasAna Ramírez de Molina
Oct 1, 2013·European Journal of Nutrition·Antonio González-SarríasJuan Carlos Espín

❮ Previous
Next ❯

Citations

May 26, 2016·Critical Reviews in Food Science and Nutrition·Rosa M Lamuel-Raventos, Marie-Pierre St Onge
Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Amany I YousefEman H Yassin
May 23, 2018·Critical Reviews in Food Science and Nutrition·Arpita Banerjee, Pubali Dhar
Jun 7, 2018·The Journal of Pharmacology and Experimental Therapeutics·Marta Gómez de CedrónAna Ramírez de Molina
Dec 17, 2017·Pharmacological Reviews·Sébastien FoulquierW Matthijs Blankesteijn
Sep 15, 2020·Frontiers in Oncology·Xiaobo NieWei-Dong Chen
Jun 9, 2016·World Journal of Gastroenterology : WJG·Seyedeh Farnaz Ghasemi-NiriMohammad Abdollahi
Mar 2, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Amany I YousefMohamed A Abdel Mohsen
Sep 19, 2018·International Journal of Biological Macromolecules·Mehak GulzarMd Imtaiyaz Hassan
Dec 1, 2021·Biotechnology and Applied Biochemistry·Arash MohammadinejadReza Kazemi Oskuee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.