The elusive mechanotransduction machinery of hair cells

Current Opinion in Neurobiology
Bo Zhao, Ulrich Müller

Abstract

Hair cells in the mammalian cochlea are specialized sensory cells that convert mechanical signals evoked by sound waves into electrochemical signals. Several integral membrane proteins have recently been identified that are closely linked to the mechanotransduction process. Efforts are under way to determine the extent to which they are subunits of the long thought-after mechanotransduction channel. Recent findings also suggest that mechanotransduction may have a role in fine tuning the length of the stereocilia and thus in the regulation of morphological features of hair cells that are inherently linked to the mechanotransduction process.

References

Jun 9, 2001·American Journal of Human Genetics·Z M AhmedE R Wilcox
Aug 7, 2001·Human Molecular Genetics·K N AlagramamG S Hagemen
Feb 19, 2002·Nature Genetics·Sarah VreugdeKaren P Steel
Feb 21, 2002·Cell·Jeffrey R HoltPeter G Gillespie
Jul 30, 2002·American Journal of Human Genetics·Sadaf NazEdward R Wilcox
Jul 23, 2003·Nature Neuroscience·Helen J KennedyRobert Fettiplace
Apr 2, 2004·Nature·Jan SiemensUlrich Müller
Apr 2, 2004·Nature·Christian SöllnerUNKNOWN Tübingen 2000 Screen Consortium
May 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chantal M Longo-GuessKenneth R Johnson
Aug 17, 2005·Neuron·Eric A StaufferPeter G Gillespie
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony J RicciRobert Fettiplace
Nov 5, 2005·Neuron·Meredith LeMasurier, Peter G Gillespie
Feb 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mathias SenftenUlrich Müller
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zubair M AhmedThomas B Friedman
Oct 6, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark E SchneiderBechara Kachar
Oct 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maryline BeurgRobert Fettiplace
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hamilton E FarrisAnthony J Ricci
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuping JiaDavid Z Z He
Mar 31, 2009·Nature Neuroscience·Maryline BeurgAnthony J Ricci
May 19, 2009·Neuron·Nicolas GrilletUlrich Müller
Aug 28, 2009·Trends in Cell Biology·María Yáñez-MóFrancisco Sánchez-Madrid
Sep 17, 2009·Pflügers Archiv : European journal of physiology·Nicolas MichalskiChristine Petit
Oct 7, 2009·Cell·Peter G Gillespie, Ulrich Müller
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michelle R GleasonA J Hudspeth
Apr 20, 2010·Neuron·Marcos SotomayorDavid P Corey
May 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Heather M ElledgeUlrich Müller
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea LelliJeffrey R Holt
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elisa CaberlottoChristine Petit
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·M'hamed Grati, Bechara Kachar
Nov 23, 2011·The Journal of Clinical Investigation·Yoshiyuki KawashimaAndrew J Griffith
Dec 20, 2011·Trends in Neurosciences·Piotr Kazmierczak, Ulrich Müller
Jun 19, 2013·PLoS Biology·Artur A IndzhykulianGregory I Frolenkov
Oct 15, 2013·Cell·Patrick Delmas, Bertrand Coste
Oct 16, 2013·The Journal of General Physiology·Kyunghee X KimRobert Fettiplace
Apr 18, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Walter MarcottiCorné J Kros

❮ Previous
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Citations

May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Maryline BeurgRobert Fettiplace
Jul 15, 2016·Biophysical Journal·Robert Fettiplace
Oct 5, 2017·Nature Reviews. Molecular Cell Biology·Swetha E MurthyArdem Patapoutian
Dec 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Francesco GianoliAndrei S Kozlov
Nov 3, 2016·Development·Basile TarchiniMichel Cayouette
Jun 20, 2018·Integrative and Comparative Biology·Duane R McPherson
Jun 30, 2018·Physiological Genomics·Janet L Fitzakerley, George J Trachte
Nov 20, 2016·Nature Communications·Raul Araya-SecchiMarcos Sotomayor
May 31, 2018·Cold Spring Harbor Perspectives in Medicine·Jocelyn F Krey, Peter G Barr-Gillespie
Dec 28, 2019·The EMBO Journal·Christian TrötschelU Benjamin Kaupp
Nov 3, 2017·Frontiers in Cellular Neuroscience·Mary E O'SullivanAlan G Cheng
Jul 5, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Friedrich G Barth
Nov 11, 2017·Current Opinion in Neurobiology·Shuo HanAlice Y Ting
Jul 31, 2018·Neuron·Gilman DionneLawrence Shapiro
Nov 9, 2021·Frontiers in Cell and Developmental Biology·Maryna V IvanchenkoDavid P Corey

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