The embryo-placental CD15-positive "vasculogenic zones" as a source of propranolol-sensitive pediatric vascular tumors

Placenta
L SeidmannW Roth

Abstract

Propranolol-induced involution is a unique biological feature of some pediatric vascular tumors, for instance infantile hemangioma (IH), cerebral cavernoma or chorioangioma. Currently, the cellular origin of these distinct tumors is unclear. In this study, we tested the hypothesis that propranolol-responsive vascular tumors are derived from common vessel-forming CD15 + progenitor cells which occur in early gestation. The aim of this study was to identify the tumor-relevant CD15 + progenitors at the early stages of embryo-placental development. Human embryo-placental units of 4-8 weeks gestation and pediatric vascular tumors were tested for expression of the tumor-relevant markers CD15, CD31 and CD34. Placental vessel-forming progenitors were characterized by immunostaining for CD15, CD31, and CD34. In embryonic tissue, a discontinuous CD15+/CD31+/CD34 + progenitors was detected in immature vessels of the skin, neural tube, spinal and cerebral meninges. Similarly, vessels in IH and chorioangioma exhibited a co-expression of CD15, CD31, and CD34. In contrast, the majority of embryonic vessels presented a CD31+/CD34+, but CD15-negative immunophenotypic pattern. Our results suggest the existence of a CD15+ "vasculogenic zones" in t...Continue Reading

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Citations

Jun 19, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L SeidmannW Roth
Mar 30, 2018·The Journal of Biological Chemistry·Nandini MondalRobert Sackstein
Sep 20, 2018·Journal of Perinatal Medicine·Percy PacoraNicholas Kadar
Apr 3, 2020·Journal of Perinatal Medicine·Sunil JaimanChaur-Dong Hsu
Jan 6, 2019·Neurosurgical Review·Caroline ApraIsabelle Pelissou-Guyotat
Feb 6, 2021·Placenta·Larissa SeidmannWilfried Roth

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