The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies
Abstract
The eMERGE (electronic MEdical Records and GEnomics) Network is an NHGRI-supported consortium of five institutions to explore the utility of DNA repositories coupled to Electronic Medical Record (EMR) systems for advancing discovery in genome science. eMERGE also includes a special emphasis on the ethical, legal and social issues related to these endeavors. The five sites are supported by an Administrative Coordinating Center. Setting of network goals is initiated by working groups: (1) Genomics, (2) Informatics, and (3) Consent & Community Consultation, which also includes active participation by investigators outside the eMERGE funded sites, and (4) Return of Results Oversight Committee. The Steering Committee, comprised of site PIs and representatives and NHGRI staff, meet three times per year, once per year with the External Scientific Panel. The primary site-specific phenotypes for which samples have undergone genome-wide association study (GWAS) genotyping are cataract and HDL, dementia, electrocardiographic QRS duration, peripheral arterial disease, and type 2 diabetes. A GWAS is also being undertaken for resistant hypertension in ≈ 2,000 additional samples identified across the network sites, to be added to data availab...Continue Reading
References
Citations
Population biobanks and returning individual research results: mission impossible or new directions?
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
Using Electronic Health Records for Population Health Research: A Review of Methods and Applications
Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes
Development and validation of method for defining conditions using Chinese electronic medical record
Optimizing identification of resistant hypertension: Computable phenotype development and validation
Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.
Making work visible for electronic phenotype implementation: Lessons learned from the eMERGE network
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