The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies

BMC Medical Genomics
Catherine A McCartyeMERGE Team

Abstract

The eMERGE (electronic MEdical Records and GEnomics) Network is an NHGRI-supported consortium of five institutions to explore the utility of DNA repositories coupled to Electronic Medical Record (EMR) systems for advancing discovery in genome science. eMERGE also includes a special emphasis on the ethical, legal and social issues related to these endeavors. The five sites are supported by an Administrative Coordinating Center. Setting of network goals is initiated by working groups: (1) Genomics, (2) Informatics, and (3) Consent & Community Consultation, which also includes active participation by investigators outside the eMERGE funded sites, and (4) Return of Results Oversight Committee. The Steering Committee, comprised of site PIs and representatives and NHGRI staff, meet three times per year, once per year with the External Scientific Panel. The primary site-specific phenotypes for which samples have undergone genome-wide association study (GWAS) genotyping are cataract and HDL, dementia, electrocardiographic QRS duration, peripheral arterial disease, and type 2 diabetes. A GWAS is also being undertaken for resistant hypertension in ≈ 2,000 additional samples identified across the network sites, to be added to data availab...Continue Reading

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Related Concepts

Clinical Trials
Diabetes Mellitus, Non-Insulin-Dependent
Hypertensive Disease
Genome
Tribes
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Health Information Technology for Economic and Clinical Health Act
Electronic Health Records
Peripheral Arterial Diseases

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