The emergence of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis patients on inhaled antibiotics

Lung India : Official Organ of Indian Chest Society
Atqah AbdulWahabEmad Bashir Ibrahim

Abstract

Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is an important and growing issue in the care of patients with cystic fibrosis (CF), and a major cause of morbidity and mortality. The objective of the study was to describe the frequency of MDR-PA recovered from the lower respiratory samples of pediatric and adult CF patients, and its antibiotic resistance pattern to commonly used antimicrobial agents including β-lactams, aminoglycosides, and fluoroquinolones. The lower respiratory isolates of P. aeruginosa were obtained from inpatients and outpatients CF clinics from a tertiary care teaching hospital for the period from October 2014 to September 2015. The identification and antimicrobial susceptibility for all the isolates were performed by using the BD Phoenix™ and E-test in compliance with Clinical and Laboratory Standards Institute (CLSI) guidelines. A total of 61 P. aeruginosa samples were isolated from thirty CF patients from twenty families. Twelve sputum samples were positive for MDR-PA (seven nonmucoid and five mucoid isolates) from five CF patients (five families) with moderate-to-very severe lung disease given MDR-PA frequency of 19.7%. The median age of the study group was 20 (range 10-30) years. Three CF patients...Continue Reading

References

Dec 31, 2014·Annals of the American Thoracic Society·Peter J MogayzelUNKNOWN Cystic Fibrosis Foundation Pulmonary Clinical Practice Guidelines Committee

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Citations

May 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Timothy M WannierGeorge M Church
Oct 5, 2019·Multidisciplinary Respiratory Medicine·Samer HammoudehIbrahim A Janahi
Jun 4, 2020·Brazilian Journal of Biology = Revista Brasleira De Biologia·X YangJ Sheng

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Methods Mentioned

BETA
bronchoalveolar lavages
electrophoresis

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