The emergence of the vasopressin and oxytocin hormone receptor gene family lineage: Clues from the characterization of vasotocin receptors in the sea lamprey (Petromyzon marinus)

General and Comparative Endocrinology
Sally A Mayasich, Benjamin L Clarke

Abstract

The sea lamprey (Petromyzon marinus) is a jawless vertebrate at an evolutionary nexus between invertebrates and jawed vertebrates. Lampreys are known to possess the arginine vasotocin (AVT) hormone utilized by all non-mammalian vertebrates. We postulated that the lamprey would possess AVT receptor orthologs of predecessors to the arginine vasopressin (AVP)/oxytocin (OXT) family of G protein-coupled receptors found in mammals, providing insights into the origins of the mammalian V1A, V1B, V2 and OXT receptors. Among the earliest animals to diverge from the vertebrate lineage in which these receptors are characterized is the jawed, cartilaginous elephant shark, which has genes orthologous to all four mammalian receptor types. Therefore, our work was aimed at helping resolve the critical gap concerning the outcomes of hypothesized large-scale (whole-genome) duplication events. We sequenced one partial and four full-length putative lamprey AVT receptor genes and determined their mRNA expression patterns in 15 distinct tissues. Phylogenetically, three of the full-coding genes possess structural characteristics of the V1 clade containing the V1A, V1B and OXT receptors. Another full-length coding gene and the partial sequence are part...Continue Reading

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Citations

Aug 9, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sally A MayasichBenjamin L Clarke
Aug 16, 2016·General and Comparative Endocrinology·Hervé TostivintNatalia B Kenigfest
Nov 20, 2018·Journal of Neuroendocrinology·Gareth Leng, John A Russell
Mar 28, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean C LemaStephen D McCormick
Jul 10, 2020·Korean journal of family medicine·Ta LarasatiAdi Heru Sutomo
Nov 20, 2016·Clinical and Experimental Pharmacology & Physiology·Yunxuan ChenWeizhong Zhu
Mar 23, 2018·Briefings in Functional Genomics·Koh Onimaru, Shigehiro Kuraku
Aug 22, 2017·Frontiers in Endocrinology·Walter WilczynskiMario Penna
Apr 30, 2021·Nature·Constantina TheofanopoulouErich D Jarvis

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