The emergence of Zika virus and its new clinical syndromes.

Nature
Theodore C Pierson, Michael S Diamond

Abstract

Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health threat because of its potential to generate explosive epidemics and ability to cause congenital disease in the context of infection during pregnancy. Whereas much is known about the biology of related flaviviruses, the unique features of ZIKV pathogenesis, including infection of the fetus, persistence in immune-privileged sites and sexual transmission, have presented new challenges. The rapid development of cell culture and animal models has facilitated a new appreciation of ZIKV biology. This knowledge has created opportunities for the development of countermeasures, including multiple ZIKV vaccine candidates, which are advancing through clinical trials. Here we describe the recent advances that have led to a new understanding of the causes and consequences of the ZIKV epidemic.

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Methods Mentioned

BETA
nuclear translocation
glycosylation

Clinical Trials Mentioned

NCT02809443
NCT02840487
NCT02996461
NCT03014089
NCT02996890
NCT02963909
NCT02952833
NCT02937233
NCT03343626
NCT03425149

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