The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease

Mediators of Inflammation
Nikolett MartonGyörgy Nagy

Abstract

Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.

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Citations

Dec 5, 2015·Expert Review of Vaccines·Susanna EspositoNicola Principi
Aug 22, 2017·Asian-Australasian Journal of Animal Sciences·Kondreddy Eswar ReddySung Dae Lee
Dec 26, 2019·BMC Genomics·Nguyen Quoc Khanh LeBinh P Nguyen
Jul 21, 2021·Genomics, Proteomics & Bioinformatics·Haitao LuoFurong Li

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Methods Mentioned

BETA
two-hybrid
PMA
ubiquitination
confocal microscopy

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