The emerging biology of delusions.

Psychological Medicine
G K Murray

Abstract

This article examines a model of how delusions may arise, not just in schizophrenia but also in a number of neurological and psychiatric conditions, through a combination of dysregulated dopamine release from ascending midbrain pathways and reasoning bias. Negative symptoms may also be related to dopamine dysregulation, with the precise mixture of positive and negative symptoms depending on the relative degree of dopamine dysregulation in particular mesocorticolimbic circuits. Evidence for this model is examined, and predictions arising from this model are described.

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Citations

Jan 15, 2013·Schizophrenia Bulletin·Mario Maj
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Jul 17, 2012·Neuropsychobiology·Anne PankowAndreas Heinz
Dec 24, 2013·Current Psychiatry Reports·Fabio PizzaGiuseppe Plazzi

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