The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning

Experimental Neurobiology
Hyun Geun ShimSang Jeong Kim

Abstract

What is memory? How does the brain process the sensory information and modify an organism's behavior? Many neuroscientists have focused on the activity- and experience-dependent modifications of synaptic functions in order to solve these fundamental questions in neuroscience. Recently, the plasticity of intrinsic excitability (called intrinsic plasticity) has emerged as an important element for information processing and storage in the brain. As the cerebellar Purkinje cells are the sole output neurons in the cerebellar cortex and the information is conveyed from a neuron to its relay neurons by forms of action potential firing, the modulation of the intrinsic firing activity may play a critical role in the cerebellar learning. Many voltage-gated and/or Ca2+-activated ion channels are involved in shaping the spiking output as well as integrating synaptic inputs to finely tune the cerebellar output. Recent studies suggested that the modulation of the intrinsic excitability and its plasticity in the cerebellar Purkinje cells might function as an integrator for information processing and memory formation. Moreover, the intrinsic plasticity might also determine the strength of connectivity to the sub-cortical areas such as deep cer...Continue Reading

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Oct 3, 2018·International Journal of Molecular Sciences·Alberto Granato, Benjamin Dering
Mar 17, 2020·CNS Neuroscience & Therapeutics·Bing-Yu ZhangHong-Hong Zhang
May 20, 2019·Pflügers Archiv : European journal of physiology·Dong Cheol Jang, Sang Jeong Kim
Dec 18, 2020·Frontiers in Cellular Neuroscience·Isis Zhang, Huijuan Hu
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Jul 2, 2021·Molecular and Cellular Neurosciences·Cheryl BrandenburgGene J Blatt
Nov 21, 2021·Nature Communications·Benjamin M ZemelHenrique von Gersdorff
Dec 8, 2021·Cognitive, Affective & Behavioral Neuroscience·Maedeh GhasemiNasrin Mehranfard

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