The emerging crisis of drug-resistant tuberculosis in South Africa: lessons from New York City

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Richard A Murphy

Abstract

Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis have emerged as important infections in South Africa among patients infected with human immunodeficiency virus (HIV). In the face of this new epidemic, South Africa must rededicate itself to the task of tuberculosis control and treatment with a rapid, multifaceted approach. Priorities include expansion of second-line treatment capacity, investment in clinical laboratories, a system to ensure supervised treatment for all patients, and enhancement of infection control procedures. In New York City, where drug-resistant tuberculosis emerged 2 decades ago--also in the context of a large HIV-infected population and an underfunded public health infrastructure--similar steps were successful in leading to the rapid decrease in rates of drug resistance among tuberculosis isolates. With refinements based on local resource constraints, urgent measures could potentially arrest the alarming increase in multidrug-resistant and extensively drug-resistant tuberculosis cases in South Africa. Unlike many countries in sub-Saharan Africa, South Africa has the capacity to mount a rapid and large-scale response before drug-resistant tuberculosis envelops a much larger and fa...Continue Reading

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Citations

Aug 23, 2008·The Lancet Infectious Diseases·Romulus BrebanSally Blower
Feb 11, 2011·Current Infectious Disease Reports·Jeffrey HafkinJoseph J Amon
Apr 20, 2012·Nature Immunology·Inmoo Rhee, André Veillette
Aug 8, 2019·Tropical Medicine & International Health : TM & IH·Bernhard KerschbergerIza Ciglenecki
Jun 27, 2020·Trauma, Violence & Abuse·Hannabeth Franchino-OlsenLily Stevens
Feb 12, 2021·The South African Journal of Communication Disorders. Die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings·Katijah Khoza-Shangase, Marina Prodromos

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