PMID: 11927291Apr 3, 2002Paper

The emerging fields of suicide gene therapy and virotherapy

Trends in Molecular Medicine
David KirnCaroline J Springer

Abstract

Gene therapy is defined as a technology aimed at modifying the genetic component of cells for therapeutic benefit. 'Suicide genes' can be introduced into cancer cells to make them more sensitive to chemotherapeutics or toxins. Chemotherapeutic suicide gene therapy approaches are known as gene-directed enzyme prodrug therapy or gene-prodrug activation therapy. Other approaches include replacement gene therapy, antisense strategies and induction of resistance to normal cells. All gene therapy strategies share a common component, which is the need for a selective delivery vehicle or vector with tumor-targeting capabilities. This need has led to the in-depth investigation of viruses as new vectors for gene therapy.

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ScheffnerP M Howley
Jul 5, 1991·Science·M HollsteinC C Harris
Nov 1, 1995·Current Opinion in Oncology·A Traynor
Dec 6, 1996·Science·C J Sherr
Jan 1, 1997·Journal of the National Cancer Institute·J A Roth, R J Cristiano
Feb 14, 1998·Bioconjugate Chemistry·I Niculescu-DuvazC J Springer
Nov 1, 1996·Nature Biotechnology·J T DouglasD T Curiel
Apr 5, 2000·The Journal of Clinical Investigation·D H Kirn
May 3, 2000·The Journal of Clinical Investigation·C J Springer, I Niculescu-Duvaz
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·J Naitoh, A Belldegrun
Aug 1, 2012·Expert Review of Anticancer Therapy·Jaimin BhattJeremy Crew

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Citations

Dec 20, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anas El-Aneed
Sep 6, 2003·Archives of Medical Research·Kevin R Smith
Feb 4, 2005·Gene Therapy·B H Shen, T W Hermiston
Mar 24, 2005·The New England Journal of Medicine·Katherine High
Jan 12, 2008·World Journal of Gastroenterology : WJG·Nima KhalighinejadAmir Momeni
Feb 20, 2016·Drug Discovery Today·Vijay Mishra, Prashant Kesharwani
Jun 11, 2003·The Journal of Gene Medicine·Oliver Meier, Urs F Greber
Jun 4, 2004·Expert Opinion on Biological Therapy·Z Sheng Guo, David L Bartlett
Jul 23, 2004·Expert Opinion on Biological Therapy·Steve H Thorne, David H Kirn
Sep 17, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Max KullbergThomas J Anchordoquy
Feb 1, 2014·Molecular BioSystems·Spencer C AlfordPerry L Howard
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward A Sausville
Sep 24, 2005·Melanoma Research·Lee D CranmerEvan M Hersh
Sep 6, 2005·Bone·Margaret RamnaraineDenis R Clohisy
Nov 19, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Partha Roy, David J Waxman
Jan 2, 2003·Nature Reviews. Cancer·Julian Downward
Feb 21, 2006·World Journal of Gastroenterology : WJG·Andreas P Sutter, Henry Fechner
Mar 1, 2013·Hepatology International·Iván Lyra-GonzálezJuan Armendáriz-Borunda
Jan 4, 2019·Tissue Engineering and Regenerative Medicine·Seung-Woo HanJun-Won Yun
Mar 21, 2006·Molecular Cancer Therapeutics·Hugo CaldasRachel A Altura
Nov 17, 2006·Cancer Research·Margaret L RamnaraineDenis R Clohisy

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