The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient

Drug Metabolism Reviews
Jun-Sheng WangC L DeVane


P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins have physiological functions in placental tissue. Several antidepressants, antipsychotics, and anti-epileptic drugs have been found to be substrates of P-glycoprotein and other transporters. The extent that drugs pass through the placental barrier is likely influenced by drug transporters. The rational choice of psychoactive drugs to treat mental illness in women of child-bearing age should incorporate knowledge of both drug disposition as well as expected pharmacologic effects. This review summarizes the current data on drug transporters in the placental passage of medications, with a focus on medications used in clinical psychopharmacology.


Nov 11, 1976·Biochimica Et Biophysica Acta·R L Juliano, V Ling
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Cordon-CardoJ R Bertino
May 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·J P WatsonD I Brough
Aug 11, 1995·Science·M M Weissman, M Olfson
Feb 1, 1995·Clinical Pharmacokinetics·P BourgetH Fernandez
Mar 1, 1995·Archives of General Psychiatry·R J Baldessarini, A C Viguera
May 1, 1994·The Histochemical Journal·A MacFarlandC K Pearson
Jun 27, 1997·Biochemical and Biophysical Research Communications·Y NakamuraY Nagata
Jun 1, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M Trixler, T Tényi
Feb 7, 1998·The Journal of Clinical Investigation·R B KimG R Wilkinson
Feb 4, 1998·Biochemical Pharmacology·L L von MoltkeR I Shader
Sep 16, 1998·The American Journal of Cardiology·T ChowB McGovern
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Dec 31, 1998·Obstetrical & Gynecological Survey·S GuptaS Rangwani
Apr 23, 1999·Pharmaceutical Research·R B KimG R Wilkinson
Sep 28, 1999·Clinical and Experimental Pharmacology & Physiology·S SchenkerM Lee
Nov 24, 1999·The Journal of Clinical Investigation·J W SmitA H Schinkel
Dec 10, 1999·Journal of Clinical Pharmacology·D K Yu
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M UhrF Holsboer
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·S HoffmeyerU Brinkmann
Mar 30, 2000·International Journal of Clinical Pharmacology and Therapeutics·A SeeligF Wohnsland
Oct 19, 2000·Journal of the National Cancer Institute·J W JonkerA H Schinkel
Mar 7, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M KatohT Yokoi
Mar 28, 2001·Journal of Clinical Pharmacology·F LarsenK F Overø
Apr 25, 2001·British Journal of Clinical Pharmacology·A OwenB K Park
Jul 17, 2001·Journal of Clinical Pharmacology·E StörmerD J Greenblatt
Jul 17, 2001·Seminars in Perinatology·D J NewportZ N Stowe
Aug 15, 2001·Clinical Pharmacology and Therapeutics·R B KimG R Wilkinson
Dec 18, 2001·Journal of Pharmaceutical Sciences·P PávekV Palicka
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Wolfgang Löscher, Heidrun Potschka
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·M V St-PierreT Stallmach
Apr 30, 2002·Placenta·M V St-PierreK T Shiverick
May 8, 2002·British Journal of Clinical Pharmacology·Siegfried DrescherMartin F Fromm

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