The emerging landscape of single-molecule protein sequencing technologies.

Nature Methods
Javier Antonio AlfaroChirlmin Joo

Abstract

Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biological discovery and open new avenues for ultrasensitive disease diagnostics.

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Citations

Oct 21, 2021·Journal of the American Chemical Society·Yujia Qing, Hagan Bayley
Nov 4, 2021·IScience·Carlos Victor de LannoyDick de Ridder
Nov 9, 2021·Biochemical Society Transactions·Joshua T Benton, Charles Bayly-Jones
Nov 20, 2021·The Plant Journal : for Cell and Molecular Biology·Joseph SwiftC Robertson McClung

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