PMID: 15383594Sep 24, 2004Paper

The emerging pathogen Moraxella catarrhalis interacts with complement inhibitor C4b binding protein through ubiquitous surface proteins A1 and A2

The Journal of Immunology : Official Journal of the American Association of Immunologists
Therése NordströmKristian Riesbeck

Abstract

Moraxella catarrhalis ubiquitous surface protein A2 (UspA2) mediates resistance to the bactericidal activity of normal human serum. In this study, an interaction between the complement fluid phase regulator of the classical pathway, C4b binding protein (C4BP), and M. catarrhalis mutants lacking UspA1 and/or UspA2 was analyzed by flow cytometry and a RIA. Two clinical isolates of M. catarrhalis expressed UspA2 at a higher density than UspA1. The UspA1 mutants showed a decreased C4BP binding (37.6% reduction), whereas the UspA2-deficient Moraxella mutants displayed a strongly reduced (94.6%) C4BP binding compared with the wild type. In addition, experiments with recombinantly expressed UspA1(50-770) and UspA2(30-539) showed that C4BP (range, 1-1000 nM) bound to the two proteins in a dose-dependent manner. The equilibrium constants (K(D)) for the UspA1(50-770) and UspA2(30-539) interactions with a single subunit of C4BP were 13 microM and 1.1 microM, respectively. The main isoform of C4BP contains seven identical alpha-chains and one beta-chain linked together with disulfide bridges, and the alpha-chains contain eight complement control protein (CCP) modules. The UspA1 and A2 bound to the alpha-chain of C4BP, and experiments with ...Continue Reading

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Citations

Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Therése NordströmKristian Riesbeck
Jun 15, 2007·Infection and Immunity·Melanie M Pearson, Eric J Hansen
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresia HallströmKristian Riesbeck
May 2, 2009·Current Opinion in Infectious Diseases·M Laura Perez Vidakovics, Kristian Riesbeck
Feb 2, 2011·PLoS Computational Biology·Bing LiuP S Thiagarajan
Sep 18, 2015·Microbiology·Sara Schesser BartraGregory V Plano
Jul 15, 2015·The Journal of Infectious Diseases·Yu-Ching SuKristian Riesbeck
Dec 30, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guanghui LiuAnna M Blom
Sep 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monika JuskoAnna M Blom
Sep 30, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maisem LaabeiAnna M Blom
Jul 5, 2019·Clinical Microbiology Reviews·Marianne F L van den BroekSarah Lebeer
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresia HallströmAnna M Blom
Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jutamas NgampasutadolPeter A Rice
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antoine Dieudonné-VatranBarbara Albiger
Aug 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vaibhav AgarwalAnna M Blom
Jan 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresia HallströmKristian Riesbeck
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Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresia HallströmKristian Riesbeck
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanna JarvaAnna M Blom
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Jun 24, 2015·Infection and Immunity·Birendra SinghKristian Riesbeck
Feb 6, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guanghui LiuAnna M Blom
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