The Emerging Picture of Mast Cell Activation: The Complex Regulatory Network of High-Affinity Receptor for Immunoglobulin E Signaling

Biological & Pharmaceutical Bulletin
Ryo Suzuki

Abstract

It is now well known that immunoglobulin E (IgE) and mast cells (MCs) are important participants in allergic diseases. MCs contain electron-dense secretory granules which are filled with inflammatory mediators. The interaction of an allergen (antigen) with an antigen-specific IgE-bound high-affinity receptor for IgE (FcεRI) is an essential step in MC activation as well as subsequent downstream signaling events. What we know is that IgE and FcεRI activate a complex regulatory network (i.e., signaling molecules and messengers) that governs both the type of MC activation and the symptoms of allergic disease. This review focuses on recent discoveries that shed new light on FcεRI signaling networks, holding promise for the development of new therapeutic solutions in the treatment of allergic diseases.

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Citations

Dec 21, 2018·International Journal of Molecular Sciences·Chen ShaoDexin Kong
Jul 3, 2020·International Journal of Environmental Research and Public Health·Giuliano MolinariElsa Nervo
Apr 11, 2021·Current Opinion in Immunology·Ulrich BlankToshiaki Kawakami

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