Sep 3, 2016

The emerging role and clinical implication of human exonic circular RNA

RNA Biology
Dongbin Lyu, Shenglin Huang

Abstract

Circular RNA from backspliced exons (or exonic circular RNA, circRNA) is a type of covalently closed non-colinear RNA that was recently rediscovered in eukaryotes. Although circRNAs are often expressed at low levels, emerging evidence indicates that many circRNAs are linked to physiological development and various diseases. Notably, circRNAs have been shown to serve as oncogenic stimuli or tumor suppressors in cancer. circRNAs may regulate gene expression through different mechanisms. In addition, circRNAs have been shown to be useful as biomarkers of diseases due to their stability, specific expression and relation to diseases both in cells and in extracellular fluid. This review summarizes current knowledge of human circRNAs and discusses the emerging role and clinical implication of these multifarious transcripts.

  • References60
  • Citations21

References

Mentioned in this Paper

Biological Markers
Tumor Suppressor Genes
RNA, circular
Exons
RNA, Untranslated
Exon-exon Junction Complex Location
Neoplasms
RNA, Small Temporal
Extracellular Fluid
Tumor Markers

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.